Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions

被引：141
|
作者：
Kuljanin, J
Jankovic, I
Nedeljkovic, J
Prstojevic, D
Marinkovic, V
机构：
[1] Vinca INst Nucl Sci, Lab Radiat Chem & Phys, YU-11001 Belgrade, Yugoslavia
[2] ZDRAVLJE Pharmaceut & Chem Ind, Qual Control Sector, YU-16000 Leskovac, Yugoslavia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 28卷 / 06期
关键词：
complex formation; alendronate; iron(III) chloride; spectrophotometry;
D O I：
10.1016/S0731-7085(02)00021-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K'(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：1215 / 1220
页数：6
相关论文
共 50 条
  • [1] SPECTROPHOTOMETRIC DETERMINATION OF FUROSEMIDE AS ITS FE(III) COMPLEX IN PHARMACEUTICAL PREPARATIONS
    ZIVANOVIC, L
    AGATONOVIC, S
    RADULOVIC, D
    MIKROCHIMICA ACTA, 1990, 1 (1-2) : 49 - 54
  • [2] Flow Injection Spectrophotometric Determination of Dipyrone in Pharmaceutical Formulations Using Fe(III) as Reagent
    Suarez, Willian T.
    Pessoa-Neto, Osmundo D.
    Vicentini, Fernando C.
    Janegitz, Bruno C.
    Faria, Ronaldo C.
    Fatibello-Filho, Orlando
    ANALYTICAL LETTERS, 2011, 44 (1-3) : 340 - 348
  • [3] Spectrophotometric and Fluorometric Methods for the Determination of Fe(III) Ions in Water and Pharmaceutical Samples
    Shahat, Ahmed
    Elamin, Nuha Y.
    Abd El-Fattah, Wesam
    ACS OMEGA, 2022, 7 (01): : 1288 - 1298
  • [4] Potentiometric determination of alendronate in pharmaceutical formulations
    Moreno, AD
    Pezza, HR
    Pezza, L
    CHEMIA ANALITYCZNA, 2004, 49 (03): : 351 - 357
  • [5] Spectrophotometric determination of four macrolide antibiotics in pharmaceutical formulations and biological fluids via binary complex formation with eosin and spectrophotometry
    Walash, Mohamed I.
    Rizk, Mohamed S.
    Eid, Manal I.
    Fathy, Mona E.
    JOURNAL OF AOAC INTERNATIONAL, 2007, 90 (06) : 1579 - 1587
  • [6] Spectrophotometric determination of four macrolide antibiotics in pharmaceutical formulations and biological fluids via binary complex formation with eosin and spectrophotometry
    Walash, Mohamed I.
    Rizk, Mohamed S.
    Eid, Manal I.
    Fathy, Mona E.
    Journal of AOAC International, 1600, 90 (06): : 1579 - 1587
  • [7] Spectrophotometric Determination of Gemifloxacin Mesylate in Pharmaceutical Formulations Through Ion-Pair Complex Formation
    Krishna, Marothu Vamsi
    Sankar, Dannana Gowri
    E-JOURNAL OF CHEMISTRY, 2008, 5 (03) : 515 - 520
  • [8] Spectrophotometric determination of carbinoxamine maleate in pharmaceutical formulations by ternary complex formation with Cu(II) and eosin
    Ramadan, A. A.
    Mandil, H.
    ANALYTICAL BIOCHEMISTRY, 2006, 353 (01) : 133 - 137
  • [9] Spectrophotometric determination of lercanidipine in pharmaceutical formulations
    Saradhi, SV
    Himabindu, V
    Rao, GD
    ASIAN JOURNAL OF CHEMISTRY, 2006, 18 (01) : 718 - 720
  • [10] Spectrophotometric determination of irinotecan in pharmaceutical formulations
    Balaram, V. Murau
    Rao, J. Venkateswara
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (06) : 4205 - 4211
12345