Structural characterization and DNA-binding properties of Sm(III) complex with ofloxacin using spectroscopic methods

被引：13
|
作者：
Chen, Changyun [1 ]
Chen, Kai [1 ]
Long, Qi [1 ]
Ma, Meihua [1 ]
Ding, Fei [1 ]
机构：
[1] Nanjing Xiaozhuang Univ, Dept Chem, Nanjing 210017, Peoples R China
来源：
SPECTROSCOPY-AN INTERNATIONAL JOURNAL | 2009年 / 23卷 / 02期
关键词：
Sm complex with ofloxacin; structural characterization; DNA-binding properties; CO(II); ZN(II);
D O I：
10.1155/2009/769146
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel complex Sm(III) complex with ofloxacin was synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, thermal analysis (TG-DSC), H-1-NMR spectra. Then, spectrometric titration, ethdium bromide displacement experiments by UV spectroscopy, ionic influence, viscosity measurements and Circular Dichroism (CD) spectroscopic measurements were conducted to characterize the interaction between the complex and CT-DNA. Results obtained indicate that the complex bound with CT-DNA via an intercalation mechanism. The binding constants and binding sites number of the Sm(III) complex with CT-DNA were 1.80 x 10(5) l.mol(-1) and 1, respectively.
引用
收藏
页码：103 / 111
页数：9
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