EARLY T-CELL PRECURSOR (ETP) ACUTE LYMPHOBLASTIC LEUKEMIA IS CHARACTERIZED BY ABERRANT ACTIVATION OF THE JAK/STAT PATHWAY AND PROFOUND RESPONSES TO RUXOLITINIB IN XENOGRAFT MODELS

被引:0
|
作者
Maude, S. L. [1 ]
Dolai, S. [2 ]
Delgado-Martin, C. [3 ]
Hunger, S. P.
Loh, M. L. [3 ]
Mullighan, C. G. [4 ,5 ]
Hermiston, M. L. [3 ]
Grupp, S. A. [1 ]
Lock, R. [2 ]
Teachey, D. T. [1 ]
机构
[1] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
[2] Childrens Canc Inst Australia Med Res, Randwick, NSW, Australia
[3] UCSF Benioff Childrens Hosp, San Francisco, CA USA
[4] Childrens Hosp Colorado, BMT, Aurora, CO USA
[5] St Jude Childrens Res Hosp, Memphis, TN 38105 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
O-013
引用
收藏
页码:S109 / S109
页数:1
相关论文
共 50 条
  • [1] Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
    Maude, Shannon L.
    Dolai, Sibasish
    Delgado-Martin, Cristina
    Vincent, Tiffaney
    Robbins, Alissa
    Selvanathan, Arthavan
    Ryan, Theresa
    Hall, Junior
    Wood, Andrew C.
    Tasian, Sarah K.
    Hunger, Stephen P.
    Loh, Mignon L.
    Mullighan, Charles G.
    Wood, Brent L.
    Hermiston, Michelle L.
    Grupp, Stephan A.
    Lock, Richard B.
    Teachey, David T.
    [J]. BLOOD, 2015, 125 (11) : 1759 - 1767
  • [2] Targeting the Jak/Stat signaling pathway is highly effective in xenograft models of early T cell precursor (ETP) acute lymphoblastic leukemia (ALL)
    Maude, Shannon L.
    Dolai, Sibasish
    Delagdo-Martin, Cristina
    Vincent, Tiffaney
    Robbins, Alissa
    Selvanathan, Arthavan
    Ryan, Theresa
    Hunger, Stephen P.
    Loh, Mignon L.
    Mullighan, Charles G.
    Wood, Brent L.
    Hermiston, Michelle L.
    Grupp, Stephan A.
    Lock, Richard B.
    Teachey, David T.
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [3] SOCS3 deregulation contributes to aberrant activation of the JAK/STAT pathway in precursor T-cell neoplasms
    Lahera, Antonio
    Lopez-Nieva, Pilar
    Alarcon, Hernan
    Marin-Rubio, Jose L.
    Cobos-Fernandez, Maria A.
    Fernandez-Navarro, Pablo
    Fernandez, Agustin F.
    Vela-Martin, Laura
    Sastre, Isabel
    Ruiz-Garcia, Sara
    Llamas, Pilar
    Lopez-Lorenzo, Jose L.
    Cornago, Javier
    Santos, Javier
    Fernandez-Piqueras, Jose
    Villa-Morales, Maria
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2023, 201 (04) : 718 - 724
  • [4] STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia
    Tremblay, Cedric S.
    Saw, Jesslyn
    Boyle, Jacqueline A.
    Haigh, Katharina
    Litalien, Veronique
    McCalmont, Hannah
    Evans, Kathryn
    Lock, Richard B.
    Jane, Stephen M.
    Haigh, Jody J.
    Curtis, David J.
    [J]. BLOOD, 2023, 142 (03) : 274 - 289
  • [5] Outcomes of adult patients with early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) and non-ETP T-ALL
    Yasushi Onishi
    Eijiro Furukawa
    Mayumi Kamata
    Masahiko Fukatsu
    Yoshihiro Kameoka
    Shunsuke Hatta
    Hiroyuki Hamada
    Tatsuo Oyake
    Tatsuyuki Kai
    Masumi Sukegawa
    Shinji Nakajima
    Ryo Yanagiya
    Kohei Yamaguchi
    Taro Takahashi
    Yoriko Harazaki
    Toru Izumi
    Kazunori Murai
    Shigeki Ito
    Takayuki Ikezoe
    Kenichi Ishizawa
    Naoto Takahashi
    Hideo Harigae
    [J]. International Journal of Hematology, 2023, 117 : 738 - 747
  • [6] Outcomes of adult patients with early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) and non-ETP T-ALL
    Onishi, Yasushi
    Furukawa, Eijiro
    Kamata, Mayumi
    Fukatsu, Masahiko
    Kameoka, Yoshihiro
    Hatta, Shunsuke
    Hamada, Hiroyuki
    Oyake, Tatsuo
    Kai, Tatsuyuki
    Sukegawa, Masumi
    Nakajima, Shinji
    Yanagiya, Ryo
    Yamaguchi, Kohei
    Takahashi, Taro
    Harazaki, Yoriko
    Izumi, Toru
    Murai, Kazunori
    Ito, Shigeki
    Ikezoe, Takayuki
    Ishizawa, Kenichi
    Takahashi, Naoto
    Harigae, Hideo
    [J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2023, 117 (05) : 738 - 747
  • [7] Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Is a High-Risk Subtype in Adults
    Jain, Nitin
    Lamb, Audrey
    O'Brien, Susan M.
    Ravandi, Farhad
    Konopleva, Marina
    Jabbour, Elias
    Zuo, Zhuang
    Jorgensen, Jeffrey L.
    Lin, Pei
    Pierce, Sherry
    Thomas, Deborah A.
    Rytting, Michael
    Borthakur, Gautam
    Kadia, Tapan
    Cortes, Jorge E.
    Kantarjian, Hagop M.
    Khoury, Joseph D.
    [J]. BLOOD, 2015, 126 (23)
  • [8] STAT5 ACTIVATION PROMOTES PROGRESSION AND CHEMOTHERAPY-RESISTANCE IN EARLY T-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
    Tremblay, Cedric
    Saw, Jesslyn
    Boyle, Jacqueline
    Haigh, Katharina
    Lock, Richard
    Jane, Stephen
    Haigh, Jody
    Curtis, David
    [J]. EXPERIMENTAL HEMATOLOGY, 2023, 124 : S151 - S151
  • [9] Comparison of Early T-Cell Precursor and Non-ETP Subtypes Among 122 Chinese Adults With Acute Lymphoblastic Leukemia
    Zhang, Yi
    Qian, Jie-Jing
    Zhou, Yi-Le
    Huang, Xin
    Li, Jian-Hu
    Li, Xue-Ying
    Li, Chen-Ying
    Wang, Huan-Ping
    Lou, Yin-Jun
    Meng, Hai-Tao
    Yu, Wen-Juan
    Tong, Hong-Yan
    Jin, Jie
    Zhu, Hong-Hu
    [J]. FRONTIERS IN ONCOLOGY, 2020, 10
  • [10] Multi-Institution Review of Adult Early T-Cell Precursor Acute Lymphoblastic Leukemia/Lymphoma (ETP-ALL)
    Shah, Bijal D.
    Borate, Uma
    Kota, Vamsi K.
    Zhang, Ling
    Peker, Deniz
    Hathaway, Amanda Redden
    Chavez, Julio C.
    [J]. BLOOD, 2015, 126 (23)