Effect of ABO Blood Group Incompatibility on the Outcome of Single-Unit Cord Blood Transplantation after Myeloablative Conditioning

被引：11

作者：

Konuma, Takaaki ^{[1
]}

Kato, Seiko ^{[1
]}

Ooi, Jun ^{[2
]}

Oiwa-Monna, Maki ^{[1
]}

Ebihara, Yasuhiro ^{[1
]}

Mochizuki, Shinji ^{[1
]}

Yuji, Koichiro ^{[1
]}

Ohno, Nobuhiro ^{[1
]}

Kawamata, Toyotaka ^{[1
]}

Jo, Norihide ^{[1
]}

Yokoyama, Kazuaki ^{[1
]}

Uchimaru, Kaoru ^{[1
]}

Tojo, Arinobu ^{[1
]}

Takahashi, Satoshi ^{[1
]}

机构：

[1] Univ Tolcyo, Inst Med Sci, Dept Hematol Oncol, Tokyo 1088639, Japan

[2] Teikyo Univ, Sch Med, Dept Hematol Oncol, Tokyo 173, Japan

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2014年 / 20卷 / 04期

关键词：

Cord blood transplantation; ABO incompatibility; Graft-versus-host disease; Myeloablative conditioning; BONE-MARROW; UNRELATED DONORS; CHRONIC GRAFT; IMPACT; GVHD;

D O I：

10.1016/j.bbmt.2013.12.563

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ABO blood group incompatibility between donor and recipient has been associated with poor transplant outcomes in allogeneic hematopoietic stem cell transplantation. However, its effect on the outcome of cord blood transplantation (CBT) has yet to be clarified. We retrospectively analyzed 191 adult patients who received single-unit CBT after myeloablative conditioning for malignant disease in our institute. Major mismatch showed a significantly lower incidence of platelet engraftment compared with ABO match as a reference (hazard ratio, .57; P =.01). Nevertheless, there was no increase in graft-versus-host disease, transplant-related mortality, and overall mortality after ABO-incompatible CBT. These data suggested that donor recipient ABO incompatibility does not have a significant impact on outcome after myeloablative CBT for hematological malignancies. (c) 2014 American Society for Blood and Marrow Transplantation.

引用

页码：577 / 581

页数：5

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