Bone marrow-derived CD45+ and CD45- cells reside in skeletal muscle

被引:5
|
作者
Issarachai, S [1 ]
Priestley, GV [1 ]
Nakamoto, B [1 ]
Papayannopoulou, T [1 ]
机构
[1] Univ Washington, Div Hematol, Seattle, WA 98195 USA
关键词
D O I
10.1006/bcmd.2002.0541
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this report we examined the kinetics of accumulation in muscle tissue of donor-derived CD45+ and CD45- cells from one to several weeks post-bone marrow transplantation. Only after hemopoiesis is fully reconstituted are CD45+ cells recovered from muscle tissue in proportions similar to ones we reported earlier in non-transplanted mice. Furthermore, using marked donor bone marrow cells, we document that in addition to CD45+ cells, donor-derived CD45- cells with certain phenotypic characteristics progressively accumulate in muscle post-transplantation. The turnover rate and physiologic roles of these populations in muscle are unclear and require further study. (C) 2002 Elsevier Science (USA).
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收藏
页码:69 / 72
页数:4
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