Formal total synthesis of borrelidin: synthesis of C1-C11 fragment via desymmetrization strategy

被引：14

作者：

Yadav, J. S. ^{[1
]}

Bezawada, Padmavani ^{[1
]}

Chenna, Venugopal ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 27期

关键词：

Borrelidin; Desymmetrization; Sharpless asymmetric epoxidation; Evan's chiral auxiliary; ANGIOGENESIS INHIBITOR; (-)-BORRELIDIN; STREPTOMYCES; ALCOHOLS;

D O I：

10.1016/j.tetlet.2009.03.196

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective formal total synthesis of borrelidin is described. The synthetic strategy for synthesis of C1-C11 fragment features desymmetrization of Diels-Alder adduct, Sharpless asymmetric epoxidation, regioselective opening of chiral epoxide, and alkylation using Evans chiral auxiliary. (C) 2009 Published by Elsevier Ltd.

引用

页码：3772 / 3775

页数：4

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