Impact of purified oat 1-3,1-4-β-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis

被引：20
|
作者：
Suchecka, D. [1 ]
Blaszczyk, K. [1 ]
Harasym, J. [2 ]
Gudej, S. [1 ]
Wilczak, J. [3 ]
Gromadzka-Ostrowska, J. [1 ]
机构：
[1] Warsaw Univ Life Sci SGGW, Chair Nutr Physiol, Dept Dietet, Fac Human Nutr & Consumer Sci, Ul Nowoursynowska 166, PL-02787 Warsaw, Poland
[2] Wroclaw Univ Econ, Fac Engn & Econ, Dept Biotechnol & Food Anal, Bioref Lab, Ul Komandorska 118-120, PL-53345 Wroclaw, Poland
[3] Warsaw Univ Life Sci SGGW, Fac Vet Med, Dept Physiol Sci, Div Dietet, Ul Nowoursynowska 166, PL-02787 Warsaw, Poland
来源：
JOURNAL OF FUNCTIONAL FOODS | 2017年 / 28卷
关键词：
Gastritis; beta-Glucan; Oat; Antioxidant; Deoxycholate; Molecular weight; HELICOBACTER-PYLORI INFECTION; LPS-INDUCED ENTERITIS; BETA-GLUCAN PROTECTS; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; CARBOHYDRATE-DIET; BOWEL-DISEASE; ORGAN INJURY; RATS;
D O I：
10.1016/j.jff.2016.10.028
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The antiinflammatory activity of purified oat 1-3,1-4-beta-d-glucan against acute gastritis (sodium deoxycholate induced) model in rats was investigated as second part of experiment studying impact of oat beta-glucan on inflammatory states in gastrointestinal tract (first part was related to enteritis). 48 rats (Spraque-Dawley males, two groups - control and gastritis) were fed high and low molecular weights (MW) beta-glucan. Antioxidant defense parameters - SOD, TAS, GSH, GSSG and inflammation markers - TBARS, TNF-alpha, IL-10 and IL-12 were analyzed. Strong activity of both fractions was observed; high MW beta-glucan caused high TNF-alpha decrease in both experimental groups while low MW beta-glucan decreased the concentration of IL-10 in gastritis group. Both fractions significantly support innate antioxidant defense of stomach tissue not only in gastritis but in healthy state as well. The results reveal the potential therapeutic activity of purified oat beta-glucan in acidic environment of stomach at acute gastritis states. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11 / 18
页数：8
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