New peptidomimetic prodrugs of acyclic and cyclic cidofovir: sat studies of chemical and enzymatic activation mechanisms

被引:3
|
作者
McKenna, Charles E. [1 ]
Peterson, Larryn W. [1 ]
Kashemirov, Boris A. [1 ]
Serpi, Michaela [1 ]
Mitchell, Stefanie [2 ]
Kim, Jae Seung [2 ]
Hilfinger, John M. [2 ]
Drach, John C. [3 ]
机构
[1] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
[2] TSRL Inc, Ann Arbor, MI USA
[3] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA
关键词
D O I
10.1016/j.antiviral.2009.02.206
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
191
引用
收藏
页码:A75 / A75
页数:1
相关论文
共 27 条
  • [1] Serine side-chain-linked peptidomimetic prodrugs of cidofovir and cyclic cidofovir: C-ester effects on transport and activation
    Peterson, Larryn W.
    Kashemirov, Boris A.
    Eriksson, Ulrika
    Kim, Jae-Seung
    Mitchell, Stefanie
    Kijek, Paul
    Lee, Kyung-Dall
    Hilfinger, John M.
    McKenna, Charles E.
    ANTIVIRAL RESEARCH, 2008, 78 (02) : A46 - A46
  • [2] Synthesis and structure-activity aspects of some cyclic cidofovir peptidomimetic prodrugs
    Peterson, Larryn W.
    Kashemirov, Boris A.
    Blazewska, Katarzyna M.
    Breitenback, Julie
    Borysko, Kathy
    Drach, John C.
    Kim, Jae Seung
    Kijek, Paul
    Hilfinger, John M.
    McKenna, Charles E.
    ANTIVIRAL RESEARCH, 2007, 74 (03) : A33 - A33
  • [3] MEDI 183-Synthesis and transport studies on serine side-chain-linked peptidomimetic prodrugs of cyclic cidofovir
    Peterson, Larryn W.
    Kashemirov, Boris A.
    Sala-Rabanal, Monica
    Kim, Jae-Seung
    Mitchell, Stefanie
    Kijek, Paul
    Hilfinger, John
    McKenna, Charles E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [4] Studies on the mechanisms of activation of indolequinone phosphoramidate prodrugs
    Hernick, M
    Borch, RF
    JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) : 148 - 154
  • [5] Syntheses, chemical and enzymatic stability of new poly(ethylene glycol)-acyclovir prodrugs
    Zacchigna, M
    Di Luca, G
    Maurich, V
    Bocca, E
    FARMACO, 2002, 57 (03): : 207 - 214
  • [6] QUANTUM CHEMICAL STUDIES ON ENZYMATIC-REACTION MECHANISMS
    UMEYAMA, H
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1982, 102 (06): : 503 - 520
  • [7] A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation
    Mata, Graca
    do Rosario, Virgilio E.
    Iley, Jim
    Constantino, Luis
    Moreira, Rui
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (02) : 886 - 892
  • [8] Quantum chemical studies of the reaction mechanisms of enzymatic CO2 conversion
    Liu, Baoyan
    Lin, Beibei
    Su, Hao
    Sheng, Xiang
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2024, 26 (42)
  • [9] N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: synthesis, chemical and enzymatic stability studies
    Bak, A
    Fich, M
    Larsen, BD
    Frokjaer, S
    Friis, GJ
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 7 (04) : 317 - 323
  • [10] MECHANISMS OF ENZYMATIC HYDROXYLATION REACTIONS - USE OF CHEMICAL-MODEL SYSTEMS IN THE STUDY OF OXYGEN ACTIVATION
    ASHOKKUMAR, A
    VAIDYANATHAN, CS
    APPAJIRAO, N
    JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH, 1978, 37 (12): : 698 - 709