Biodegradable Micro and Nanoparticles for Controlled Drug Release

被引：0
|
作者：
Mattu, C. [1 ]
Sartori, S. [1 ]
Ranzato, E. [2 ]
Boffito, M. [1 ]
Li, R. [1 ]
Ciardelli, G. [1 ]
机构：
[1] Politecn Torino, Dipartimento Meccan, Cso Duca Abruzzi 29, I-10129 Turin, Italy
[2] Univ Piemonte Orientale Amedeo Avogadro, DiSAV, Dept Environm & Life Sci, I-15121 Alessandria, Italy
来源：
NANOTECHNOLOGY 2011: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY, NSTI-NANOTECH 2011, VOL 3 | 2011年
关键词：
microparticles; nanoparticles; paclitaxel; polyurethanes; polyesters;
D O I：
暂无
中图分类号：
TE [石油、天然气工业]; TK [能源与动力工程];
学科分类号：
0807 ; 0820 ;
摘要：
In this paper, we propose the encapsulation of the anticancer drug Paclitaxel into biodegrdable polymeric carriers to improve the release properties of the active principle. Commercial polyesthers, such as Poly-epsilon-Caprolactone (PCL) or Poly Lactic Acid (PLA) and a series of proprietary polyester-urethanes (PU) were selected to prepare micro or nanoparticles for controlled drug release. The Solvent Displacement Method or the Oil in Water single Emulsion Solvent Extraction Evaporation Method were optimized to prepare colloidal carriers with tunable release profiles and encapsulation properties.
引用
收藏
页码：314 / 317
页数：4
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