Factor H-related protein 1: a complement regulatory protein and guardian of necrotic-type surfaces

被引：16
|
作者：
Skerka, Christine [1 ]
Pradel, Gabriele [2 ]
Halder, Luke D. [1 ]
Zipfel, Peter F. [1 ]
Zipfel, Svante L. H. [3 ]
Strauss, Olaf [4 ]
机构：
[1] Leibniz Inst Nat Prod Res & Infect Biol, Hans Knoll Inst, Dept Infect Biol, Jena, Germany
[2] Rhein Westfal TH Aachen, Div Cellular & Appl Infect Biol, Aachen, Germany
[3] Univ Med Ctr Hamburg Eppendorf, Univ Heart Ctr, Dept Cardiovasc Surg, Hamburg, Germany
[4] Charite, Expt Ophthalmol, Campus Virchow Clin, Berlin, Germany
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2021年 / 178卷 / 14期
关键词：
complement; factor H‐ related protein 1; inflammation; HEMOLYTIC-UREMIC SYNDROME; GENOME-WIDE ASSOCIATION; MACULAR DEGENERATION; BINDING-PROTEIN; ACTIVATION; DISEASES; MOUSE; CFHR1; LIPOPROTEIN; INSIGHTS;
D O I：
10.1111/bph.15290
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Factor H-related protein 1 (FHR-1) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, CFHR1 on human chromosome 1, is involved in diseases such as age-related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome, indicating an important role for FHR-1 in human health. Recent research data demonstrate that FHR-1 levels increase in IgA nephropathy and anti-neutrophilic cytoplasmic autoantibodies (ANCA) vasculitis and that FHR-1 induces strong inflammation in monocytes on necrotic-type surfaces, suggesting a complement-independent role. These new results increase our knowledge about the role of this complement protein in pathology and provide a new therapeutic target, particularly in the context of inflammatory diseases induced by necrosis. This review summarizes current knowledge about FHR-1 and discusses its role in complement reactions and inflammation.
引用
收藏
页码：2823 / 2831
页数：9
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