The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure

被引：107
|
作者：
Liang, Pei-Yan [1 ,2 ,3 ]
Diao, Liang-Hui [2 ,3 ]
Huang, Chun-Yu [2 ,3 ]
Lian, Ruo-Chun [2 ,3 ]
Chen, Xian [2 ,3 ]
Li, Guan-Gui [2 ,3 ]
Zhao, Jin [1 ]
Li, Yu-Ye [2 ,3 ]
He, Xue-bing [2 ,3 ]
Zeng, Yong [2 ,3 ]
机构：
[1] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China
[2] Shenzhen Zhongshan Urol Hosp, Fertil Ctr, Shenzhen Key Lab Reprod Immunol Periimplantat, Shenzhen 518045, Peoples R China
[3] Shenzhen Zhongshan Inst Reprod Med & Genet, Shenzhen 518045, Peoples R China
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2015年 / 31卷 / 06期
关键词：
anti-inflammatory cytokines; IVF/ICSI-ET; pro-inflammatory cytokines; recurrent implantation failure; NK CELLS; T-CELLS; PREGNANCY; GAMMA;
D O I：
10.1016/j.rbmo.2015.08.009
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Limited information is available on the balance state of pro- and anti-inflammatory cytokines in patients with recurrent implantation failure (RIF). This study assessed the pro- and anti-inflammatory cytokines in plasma of 34 patients with RIF, compared with those of 25 women with a successful pregnancy in the first IVF/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycle. The IFN-gamma, IL-1 beta, IL-6 and IL-4 concentrations were higher, whereas the TGF-beta 1 concentration was lower in the RIF group compared with the control group. Furthermore, the ratios of pro- inflammatory and anti-inflammatory cytokines IFN-gamma/IL-4, IFN-gamma/IL-10, IFN-gamma/TGF-beta 1, IL-6/IL-10, IL-6/TGF-beta 1, IL-1 beta/TGF-beta 1 and TNF-alpha/TGF-beta 1 were higher in the RIF group (all P < 0.01). The results suggested a shift toward a pro- inflammatory state in peripheral blood of the patients with RIF. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：823 / 826
页数：4
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