Recent advances in malaria chemotherapy

被引：8

作者：

Robert, A ^{[1
]}

Dechy-Cabaret, O ^{[1
]}

Cazelles, J ^{[1
]}

Benoit-Vical, F ^{[1
]}

Meunier, B ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2002年 / 49卷 / 03期

关键词：

artemisinin; malaria; peroxide; quinoline; trioxaquine;

D O I：

10.1002/jccs.200200046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short review of the currently used antimalarial drugs is reported. The molecular aspects of the different possible mechanisms of action of artemisinin is documented, including recent data on heme alkylation. The preparation and the in vitro antimalarial activity of new modular molecules named "trioxaquines" is also presented.

引用

页码：301 / 310

页数：10

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