Mapping Human Genetic Diversity in Asia

被引：426

作者：

Abdulla, Mahmood Ameen ^{[2
,3
]}

Ahmed, Ikhlak ^{[4
]}

Assawamakin, Anunchai ^{[5
,6
]}

Bhak, Jong ^{[7
]}

Brahmachari, Samir K. ^{[4
]}

Calacal, Gayvelline C. ^{[8
]}

Chaurasia, Amit ^{[4
]}

Chen, Chien-Hsiun ^{[9
]}

Chen, Jieming ^{[10
]}

Chen, Yuan-Tsong ^{[9
]}

Chu, Jiayou ^{[11
]}

Cutiongco-de la Paz, Eva Maria C. ^{[12
]}

De Ungria, Maria Corazon A. ^{[8
]}

Delfin, Frederick C. ^{[8
]}

Edo, Juli ^{[2
,3
]}

Fuchareon, Suthat ^{[5
]}

Ghang, Ho ^{[7
]}

Gojobori, Takashi ^{[13
,14
,15
]}

Han, Junsong ^{[16
]}

Ho, Sheng-Feng ^{[9
]}

Hoh, Boon Peng ^{[17
]}

Huang, Wei ^{[18
]}

Inoko, Hidetoshi ^{[19
]}

Jha, Pankaj ^{[4
]}

Jinam, Timothy A. ^{[2
,3
]}

Jin, Li ^{[1
,20
,40
]}

Jung, Jongsun ^{[21
]}

Kangwanpong, Daoroong ^{[22
]}

Kampuansai, Jatupol ^{[22
]}

Kennedy, Giulia C. ^{[23
,24
]}

Khurana, Preeti ^{[25
]}

Kim, Hyung-Lae ^{[21
]}

Kim, Kwangjoong ^{[21
]}

Kim, Sangsoo ^{[26
]}

Kim, Woo-Yeon ^{[7
]}

Kimm, Kuchan ^{[27
]}

Kimura, Ryosuke ^{[28
]}

Koike, Tomohiro ^{[13
,14
]}

Kulawonganunchai, Supasak ^{[6
]}

Kumar, Vikrant ^{[10
]}

Lai, Poh San ^{[29
,30
]}

Lee, Jong-Young ^{[21
]}

Lee, Sunghoon ^{[7
]}

Liu, Edison T. ^{[10
]}

Majumder, Partha P. ^{[31
]}

Mandapati, Kiran Kumar ^{[25
]}

Marzuki, Sangkot ^{[32
]}

Mitchell, Wayne ^{[33
,34
]}

Mukerji, Mitali ^{[4
]}

Naritomi, Kenji ^{[35
]}

机构：

[1] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[2] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Fac Arts & Social Sci, Dept Anthropol, Kuala Lumpur 50603, Malaysia

[4] CSIR, Inst Genom & Integrat Biol, Delhi 110007, India

[5] Mahidol Univ, Puttamonthon 73170, Nakornpathom, Thailand

[6] Natl Ctr Genet Engn & Biotechnol, Genome Inst, Biostat & Informat Lab, Pathum Thani 12120, Thailand

[7] KRIBB, KOBIC, Taejon 305806, South Korea

[8] Univ Philippines, Nat Sci Res Inst, DNA Anal Lab, Quezon City 1101, Philippines

[9] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[10] Genome Inst Singapore, Singapore 138672, Singapore

[11] Chinese Acad Med Sci, Inst Med Biol, Kunming, Peoples R China

[12] Univ Philippines Manila, Natl Inst Hlth, Inst Human Genet, Ermita Manila 1000, Philippines

[13] Res Org Informat & Syst, Ctr Informat Biol, Mishima, Shizuoka 4118540, Japan

[14] Res Org Informat & Syst, DNA Data Bank Japan, Natl Inst Genet, Mishima, Shizuoka 4118540, Japan

[15] Natl Inst Adv Ind Sci & Technol, Biomed Informat Res Ctr, Koto Ku, Tokyo 1350064, Japan

[16] Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China

[17] Univ Sains Malaysia, Sch Med Sci, Ctr Human Genome, Kubang Kerian 16150, Kelantan, Malaysia

[18] Chinese Natl Human Genome Ctr Shanghai, MOST Shanghai Lab Dis & Hlth Genom, Shanghai 201203, Peoples R China

[19] Tokai Univ, Sch Med, Dept Mol Life Sci, Div Mol Med Sci & Mol Med, Isehara, Kanagawa A2591193, Japan

[20] Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China

[21] Korea Natl Inst Hlth, Seoul 122701, South Korea

[22] Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50202, Thailand

[23] Affymetrix, Genom Collaborat, Santa Clara, CA 95051 USA

[24] Veracyte, San Francisco, CA 94080 USA

[25] Ctr Genom Applicat, New Delhi 110020, India

[26] Soongsil Univ, Seoul 156743, South Korea

[27] Eulji Univ, Coll Med, Taejon 301832, South Korea

[28] Univ Tokyo, Grad Sch Med, Dept Human Genet, Bunkyo Ku, Tokyo 1130033, Japan

[29] Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119074, Singapore

[30] DSO Natl Labs, Def Med & Environm Res Inst, Populat Genet Lab, Singapore 117510, Singapore

[31] Indian Stat Inst, Kolkata 700108, India

[32] Eijkman Inst Mol Biol, Jakarta 10430, Indonesia

[33] Informat Expt Therapeut Ctr, Singapore 138669, Singapore

[34] Nanyang Technol Univ, Sch Comp Engn, Div Informat Sci, Singapore 639798, Singapore

[35] Univ Ryukyus, Fac Med, Dept Med Genet, Okinawa 9030215, Japan

[36] Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand

[37] Monash Univ, Bandar Sunway 46150, Selangor, Malaysia

[38] RIKEN, Genom Sci Ctr, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[39] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Lab Funct Genom,Shirokanedai Lab,Minato Ku, Tokyo 1088639, Japan

[40] Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Soc, Partner Inst Computat Biol, Shanghai 200031, Peoples R China

[41] NIMH, Genom Res Branch, NIH, Bethesda, MD 20892 USA

[42] Hlth Sci Univ Hokkaido, Res Inst Personalized Hlth Sci, Tobetsu 0610293, Japan

来源：

SCIENCE | 2009年 / 326卷 / 5959期

关键词：

POPULATION-STRUCTURE; WIDE ANALYSIS; ADMIXTURE; GEOGRAPHY; UYGHURS; HISTORY; EUROPE;

D O I：

10.1126/science.1177074

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

引用

页码：1541 / 1545

页数：5

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