Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients

被引:7
|
作者
van der Torre, Mireille H. [1 ,2 ]
Shen, Hongwei [2 ]
Rautemaa-Richardson, Riina [1 ,2 ,3 ]
Richardson, Malcolm D. [1 ,2 ]
Novak-Frazer, Lilyann [1 ,2 ]
机构
[1] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Mycol Reference Ctr Manchester, ECMM Ctr Excellence Clin & Lab Mycol & Clin Studi, Manchester M23 9LT, Lancs, England
[2] Univ Manchester, Fac Biol Med & Hlth, Div Infect Inflammat & Resp Med, Manchester M13 9PL, Lancs, England
[3] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Dept Infect Dis, Manchester M23 9LT, Lancs, England
关键词
Aspergillus fumigatus; molecular epidemiology; chronic pulmonary aspergillosis; genotyping; genetic diversity; SINGLE NUCLEOTIDE POLYMORPHISMS; AZOLE RESISTANCE; TRIAZOLE-RESISTANCE; TYPING METHODS; NOSOCOMIAL ASPERGILLOSIS; INVASIVE ASPERGILLOSIS; TR34/L98H MUTATIONS; GENETIC DIVERSITY; CYSTIC-FIBROSIS; TANDEM REPEATS;
D O I
10.3390/jof7020152
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience.
引用
收藏
页码:1 / 20
页数:19
相关论文
共 50 条
  • [1] Pulmonary aspergillosis and Aspergillus fumigatus
    Martins, C
    [J]. COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES, 1928, 99 : 953 - 955
  • [2] Treatment outcome in patients with chronic pulmonary aspergillosis by azole-resistant aspergillus fumigatus
    Takeda, Keita
    Suzuki, Junko
    Nagai, Hideaki
    Kawashima, Masahiro
    Ohsima, Nobuharu
    Tamura, Atsuhisa
    Akagawa, Shinobu
    Matsui, Hirotoshi
    Ohta, Ken
    Watanabe, Akira
    Kamei, Katsuhiko
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2016, 48
  • [3] Non-fumigatus Aspergillus Infection Associated with a Negative Aspergillus Precipitin Test in Patients with Chronic Pulmonary Aspergillosis
    Takeda, Keita
    Suzuki, Junko
    Watanabe, Akira
    Narumoto, Osamu
    Kawashima, Masahiro
    Sasaki, Yuka
    Nagai, Hideaki
    Kamei, Katsuhiko
    Matsui, Hirotoshi
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2022, 60 (02)
  • [4] IMMUNOGLOBULIN CLASSES OF ANTIBODIES TO ASPERGILLUS-FUMIGATUS IN PATIENTS WITH PULMONARY ASPERGILLOSIS
    WARNOCK, DW
    ELDRED, GF
    [J]. SABOURAUDIA-JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 1975, 13 (JUL): : 204 - 208
  • [5] Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis
    Howard, S. J.
    Pasqualotto, A. C.
    Anderson, M. J.
    Leatherbarrow, H.
    Albarrag, A. M.
    Harrison, E.
    Gregson, L.
    Bowyer, P.
    Denning, D. W.
    [J]. MYCOSES, 2013, 56 (04) : 434 - 441
  • [6] Aspergillus fumigatus strains are adapted to the lung environment in a case of chronic pulmonary aspergillosis
    Gago, S.
    Khateb, A.
    Soto-Debran, J. C.
    Moore, C. B.
    Denning, D. W.
    Bowyer, P.
    [J]. MEDICAL MYCOLOGY, 2018, 56 : S50 - S50
  • [7] Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis
    Takahashi-Nakaguchi, Azusa
    Muraosa, Yasunori
    Hagiwara, Daisuke
    Sakai, Kanae
    Toyotome, Takahito
    Watanabe, Akira
    Kawamoto, Susumu
    Kamei, Katsuhiko
    Gonoi, Tohru
    Takahashi, Hiroki
    [J]. MEDICAL MYCOLOGY, 2015, 53 (04) : 353 - 360
  • [8] Nasal, pulmonary and abomasal Aspergillosis (Aspergillus fumigatus) in a Calf
    Breuer, W.
    Stoll, A.
    Hoermansdorfer, S.
    Knubben-Schweizer, G.
    Hafner-Marx, A.
    Deischl, K.
    [J]. SCHWEIZER ARCHIV FUR TIERHEILKUNDE, 2015, 157 (07): : 407 - 411
  • [9] Aspergillus fumigatus and aspergillosis
    Latgé, JP
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (02) : 310 - +
  • [10] SERUM ANTIBODIES TO ASPERGILLUS-FUMIGATUS IN PATIENTS WITH PULMONARY ASPERGILLOSIS DETECTED BY IMMUNOFLUORESCENCE
    SCHONHEYDER, H
    ANDERSEN, P
    STENDERUP, A
    [J]. ACTA PATHOLOGICA MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA SECTION B-MICROBIOLOGY, 1982, 90 (04): : 273 - 279