Optimal switching in structured treatment interruption for HIV therapy

被引：0
|
作者：
Kim, Won Hee [1 ]
Chung, Han Byul
Chung, Choo Chung
机构：
[1] Hanyang Univ, Div Elect & Comp Engn, Seoul 133791, South Korea
[2] Samsung Elect, Telecommun Network Business, Suwon 442600, Kyunggi Do, South Korea
[3] Hanyang Univ, Div Elect & Comp Engn, Seoul 133791, South Korea
[4] Hanyang Univ, Div Elect & Biomed Engn, Seoul 133791, South Korea
来源：
ASIAN JOURNAL OF CONTROL | 2006年 / 8卷 / 03期
关键词：
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
This paper proposes 'optimal switching control during structured treatment interruption, which switches RTI and PI to reduce medication and establish long-term immune response against HIV. The proposed method is compared with 'optimized STI' through numerical simulation. The proposed method results in a more rapid increase of CTLp, and thus total drug intake and the therapy period are reduced. HIV treatment simulation results are analyzed in terms of controllability. Due to the effect of PI, 'optimal switching control during STI' can achieve greater controllability more quickly than 'optimized STI'.
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收藏
页码：290 / 296
页数：7
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