This paper presents the results of an experimental study on rectangular RC columns strengthened with carbon fiber-reinforced polymer (CFRP) composites under axial load and biaxial bending moment. A total of 8 large-scale RC columns with rectangular cross-section were cast and tested under bi-eccentric compressive loading up to failure. In this investigation, several parameters like CFRP thickness of one, two, three, and four layers, fiber orientations of +/-45 degrees, 0 degrees, 90 degrees and their combination, and eccentricities in the direction of both weak and main axis were studied. The effects of these parameters on the moment-curvature relationship, and load-longitudinal displacement relationship were investigated. In general, increasing longitudinal layers rather than transverse layers led to a greater load carrying and displacement capacity of the specimens, because of the overall behavior of RC wall-like columns. The results of these experimental and numerical studies showed a great improvement on the strength and ductility of confined RC columns. (C) 2013 Elsevier Ltd. All rights reserved.