Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene

被引：42

作者：

Gunn, Shelly R. ^{[1
,2
]}

Bolla, Aswani R. ^{[1
]}

Barron, Lynn L. ^{[3
]}

Gorre, Mercedes E. ^{[2
]}

Mohammed, Mansoor S. ^{[2
]}

Bahler, David W. ^{[6
,7
]}

Mellink, Clemens H. M. ^{[8
]}

van Oers, Marinus H. J. ^{[9
]}

Keating, Michael J. ^{[4
]}

Ferrajoli, Alessandra ^{[4
]}

Coombes, Kevin R. ^{[5
]}

Abruzzo, Lynne V. ^{[3
]}

Robetorye, Ryan S. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX USA

[2] Combimatrix Mol Diagnost Inc, Irvine, CA USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[6] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[7] Univ Utah, ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA

[8] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands

[9] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 09期

关键词：

Chronic lymphocytic leukemia; Array CGH; Chromosome; 22q11; PRAME gene; ANTIGEN; EXPRESSION; MELANOMA; DISORDERS;

D O I：

10.1016/j.leukres.2008.10.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases. Submicroscopic deletions of chromosome 22q11 were observed in 28 cases (15%), and the frequency of these deletions was second only to loss of the 13q14 region, the most common genomic aberration in CLL Oligonucleotide-based array CGH analysis showed that the 22q11 deletions ranged in size from 0.34 Mb up to similar to 1 Mb. The minimally deleted region included the ZNF280A, ZNF280B, GGTLC2, and PRAME genes. Quantitative real-time PCR revealed that ZNF280A, ZNF280B, and PRAME mRNA expression was significantly lower in the 22q11 deletion cases compared to non-deleted cases. Published by Elsevier Ltd.

引用

页码：1276 / 1281

页数：6

共 11 条

[1] Array CGH Analysis of Chronic Lymphocytic Leukemia Reveals Frequent Cryptic Monoallelic and Biallelic Deletions of Chromosome 22q11.
McClain, William D.
Gunn, Shelly R.
Bolla, Aswani R.
Barron, Lynn L.
Gorre, Mercedes E.
Bahler, David W.
Mellink, Clemens H. M.
van Oers, Marinus H. J.
Keating, Michael J.
Ferrajoli, Alessandra
Coombes, Kevin R.
Abruzzo, Lynne V.
Robetorye, Ryan S.
BLOOD, 2008, 112 (11) : 384 - 385
[2] ARRAY CGH ANALYSIS REVEALS DELETION OF CHROMOSOME 22Q11 IN CLL WITH NORMAL KARYOTYPE AND NO FISH ALTERATIONS
Mestichelli, F.
Dalsass, A.
Ferretti, S.
Camaioni, E.
Angelini, M.
Mei, S.
Pezzoni, V.
Travaglini, F.
Troiani, E.
Angelini, S.
Galieni, P.
HAEMATOLOGICA, 2016, 101 : 427 - 427
[3] Array CGH analysis reveals deletion of chromosome 22q11 in CLL with normal karyotype and no fish alterations
Mestichelli, Francesca
Dalsass, Alessia
Ferretti, Silvia
Camaioni, Elisa
Angelini, Mario
Mei, Sabrina
Pezzoni, Valerio
Travaglini, Fosco
Troiani, Emanuela
Angelini, Stefano
Galieni, Piero
BRITISH JOURNAL OF HAEMATOLOGY, 2018, 183 (01) : 152 - 155
[4] Atypical 11q deletions identified by array CGH may be missed by FISH panels for prognostic markers in chronic lymphocytic leukemia
S R Gunn
M K Hibbard
S H Ismail
M Lowery-Nordberg
C H M Mellink
D W Bahler
L V Abruzzo
E L Enriquez
M E Gorre
M S Mohammed
R S Robetorye
Leukemia, 2009, 23 : 1011 - 1017
[5] Atypical 11q Deletions Identified by Array CGH May Be Missed by FISH Panels for Prognostic Markers in Chronic Lymphocytic Leukemia
Mammarappallil, M. C.
Gunn, S. R.
Hibbard, M. K.
Lowery-Nordberg, M.
Enriquez, E. L.
Gorre, M. E.
Mohammed, M. S.
Robetorye, R. S.
LABORATORY INVESTIGATION, 2009, 89 : 374A - 374A
[6] Atypical 11q deletions identified by array CGH may be missed by FISH panels for prognostic markers in chronic lymphocytic leukemia
Gunn, S. R.
Hibbard, M. K.
Ismail, S. H.
Lowery-Nordberg, M.
Mellink, C. H. M.
Bahler, D. W.
Abruzzo, L. V.
Enriquez, E. L.
Gorre, M. E.
Mohammed, M. S.
Robetorye, R. S.
LEUKEMIA, 2009, 23 (05) : 1011 - 1017
[7] Atypical 11q Deletions Identified by Array CGH May Be Missed by FISH Panels for Prognostic Markers in Chronic Lymphocytic Leukemia
Mammarappallil, M. C.
Gunn, S. R.
Hibbard, M. K.
Lowery-Nordberg, M.
Enriquez, E. L.
Gorre, M. E.
Mohammed, M. S.
Robetorye, R. S.
MODERN PATHOLOGY, 2009, 22 : 374A - 374A
[8] High-density oligonucleotide tiling array based Very-High Resolution CGH and its application to the analysis of breakpoints in Chromosome 22Q and in 22Q11 Deletion Syndrome
Urban, Alexander Eckehart
Korbel, Jan
Grubert, Fabian
Selzer, Rebecca
Richmond, Todd
Hacker, April
Green, Roland
Emanuel, Beverly S.
Gerstein, Mark
Weissman, Sherman M.
Snyder, Michael
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (07) : 698 - 698
[9] FREQUENT HOMOZYGOUS DELETIONS OF THE D13S25 LOCUS IN CHROMOSOME REGION 13Q14 DEFINES THE LOCATION OF A GENE CRITICAL IN LEUKEMOGENESIS IN CHRONIC B-CELL LYMPHOCYTIC-LEUKEMIA
CHAPMAN, RM
CORCORAN, MM
GARDINER, A
HAWTHORN, LA
COWELL, JK
OSCIER, DG
ONCOGENE, 1994, 9 (04) : 1289 - 1293
[10] C22orf2 Gene (22q13.1) Translocation Downstream of Bcr Breakpoint (22q11) to the Derivative 9 Chromosome Is Associated with Reduced Expression of Its Protein, the Beta-Catenin Antagonist Chibby, in Chronic Myeloid Leukemia Progenitors
Aluigi, Michela
Mancini, Manuela
Leo, Elisa
Castagnetti, Fausto
Baldazzi, Carmen
Barbieri, Enza
Santucci, Maria Alessandra
BLOOD, 2011, 118 (21) : 727 - 728

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