DIELS-ALDER REACTION OF 2-(CYCLIC AMINO)-SUBSTITUTED 3-FURANCARBONITRILES WITH MALEIMIDES TO PHTHALIMIDES

被引：4

作者：

Maruoka, Hiroshi ^{[1
]}

Okabe, Fumi ^{[1
]}

Koutake, Yoshimichi ^{[1
]}

Fujioka, Toshihiro ^{[1
]}

Yamagata, Kenji ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

来源：

HETEROCYCLES | 2009年 / 77卷 / 01期

关键词：

Diels-Alder Reaction; Cycloaddition; Furan; Phthalimide; Maleimide; FACTOR-ALPHA PRODUCTION; VERSUS-HOST-DISEASE; MICROWAVE IRRADIATION; ANTIINFLAMMATORY ACTIVITY; THALIDOMIDE; FURANS; ANILINES; ANALOGS; DERIVATIVES; ANHYDRIDES;

D O I：

10.3987/COM-08-S(F)34

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Diels-Alder reaction is described in the furan series, leading to phthalimides in high yields. Thermal treatment of 2-(4-morpholinyl, 1-piperidinyl, and 1-pyrrolidinyl)-3-furancarbortitfiles with maleimide derivatives, e.g. maleimide, N-methylmaleimide, N-benzylmaleimide, N-phenylmaleimide and N-(4-nitrophenyl)maleimide, in boiling acetic acid caused a [4 + 2] cycloaddition reaction to give the corresponding phthalimide derivatives.

引用

页码：617 / 628

页数：12

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