Gastrointestinal bleeding in von Willebrand disease

被引：49
|
作者：
Makris, M [1 ]
机构：
[1] Royal Hallamshire Hosp, Sheffield Haemophilia & Thrombosis Ctr, Sheffield S10 2JF, S Yorkshire, England
来源：
THROMBOSIS RESEARCH | 2006年 / 118卷
关键词：
angiodysplasia; aortic stenosis; gastrointestinal bleeding; haemorrhage; von Willebrand disease; von Willebrand factor;
D O I：
10.1016/j.thromres.2006.01.022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gastrointestinal bleeding due to colonic angiodysplasia is a well-recognised complication of von Willebrand disease (vWD), occurring almost exclusively in subtypes of the disease associated with a reduction in high-molecular-weight (HMW) multimers of von Willebrand factor (vWF). A deficiency of vWF HMW multimers also provides the link between aortic stenosis and gastrointestinal (GI) bleeding in Heyde's syndrome. The diagnosis and treatment of the angiodysplastic bleeding in vWD can be very difficult and the role of vWF containing concentrates in treatment and prophylaxis remains to be established. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S13 / S17
页数：5
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