Organocatalytic Aerobic Oxidation of Benzylic sp3 C-H Bonds of Ethers and Alkylarenes Promoted by a Recyclable TEMPO Catalyst

被引：80
|
作者：
Zhang, Zhiguang [1 ,2 ]
Gao, Yuan [1 ,2 ]
Liu, Yuan [1 ,2 ]
Li, Jianjun [1 ,2 ]
Xie, Hexin [1 ,2 ]
Li, Hao [1 ,2 ]
Wang, Wei [1 ,2 ,3 ]
机构：
[1] E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China
[3] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 21期
基金：
美国国家科学基金会;
关键词：
TRANSITION-METAL-FREE; HIGHLY EFFICIENT; ALCOHOLS; OXYGEN; AMINES; FUNCTIONALIZATION; ARYLMETHYLENE; ACTIVATION; NITROXIDES; ALDEHYDES;
D O I：
10.1021/acs.orglett.5b02877
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An entirely metal-free catalyst system consisting of an easily prepared recyclable new TEMPO derived sulfonic salt catalyst, and mineral acids (NaNO2 and HCl) has been developed for selective aerobic oxidation of structurally diverse benzylic sp(3) C-H bonds of ethers and alkylarenes. The mild reaction conditions allow for the generation of synthetically and biologically valued isochromanones and xanthones from readily accessible alkyl aromatic precursors in good yields.
引用
收藏
页码：5492 / 5495
页数：4
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