Enantiospecific Generation and Trapping Reactions of Aryne Atropisomers

被引：16

作者：

Wei, Yun-Long ^{[1
]}

Dauvergne, Guillaume ^{[1
]}

Rodriguez, Jean ^{[1
]}

Coquerel, Yoann ^{[1
]}

机构：

[1] Aix Marseille Univ, F-13397 Marseille, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 40期

关键词：

EFFICIENT; CHIRALITY; BIARYLS; BENZYNE; ACCESS;

D O I：

10.1021/jacs.0c08218

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioenriched aryne atropisomers having a biaryl stereogenic axis vicinal to the reactive triple bond are demonstrated to exist. These reaction intermediates are easily produced in situ and can undergo the standard aryne cycloaddition chemistry in an enantiospecific manner. Notably, the aryne atropisomers herein have allowed the practical syntheses of a small nanographene as well as some triptycene and anthracene derivatives that embed stereogenic axes of controlled absolute configurations.

引用

页码：16921 / 16925

页数：5

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