The antipyretic effect of NG-nitro-L-arginine methyl ester is related to its influence on metabolism

被引：6
|
作者：
Matuszek, MT [1 ]
机构：
[1] Med Univ Gdansk, Dept Pharmacol, PL-80227 Gdansk, Poland
来源：
JOURNAL OF THERMAL BIOLOGY | 2000年 / 25卷 / 1-2期
关键词：
body temperature; L-NAME; LPS fever; metabolic rare; rabbits;
D O I：
10.1016/S0306-4565(99)00071-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Thermoregulatory responses (rectal and ear skin temperatures, metabolic rate, respiratory rate), after treatment with N-G-nitro-L-arginine methyl ester (L-NAME), were investigated in normothermic and febrile rabbits at an ambient temperature of 20 +/- 1 degrees C. In endotoxin challenged rabbits, L-NAME (25 mg/kg i.v.) given 30 min before LPS (1 mu g/kg i.v.) significantly reduced fever response, while did not influence body temperature in saline treated animals. The antipyretic action of L-NAME was caused mainly due to inhibition of metabolic rate. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：59 / 63
页数：5
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