Systemic treatments for brain metastases from breast cancer, non-small cell lung cancer, melanoma and renal cell carcinoma: An overview of the literature

被引：47
|
作者：
Lombardi, Giuseppe [1 ]
Di Stefano, Anna Luisa [2 ,3 ]
Farina, Patrizia [1 ]
Zagonel, Vittorina [1 ]
Tabouret, Emeline [4 ,5 ]
机构：
[1] Veneto Inst Oncol IOV IRCCS, Padua, Italy
[2] Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol, F-75013 Paris, France
[3] Univ Pavia, Natl Neurol Inst C Mondino, I-27100 Pavia, Italy
[4] Timone Hosp, APHM, Marseille, France
[5] Aix Marseille Univ, CRO2, UMR911, Marseille, France
来源：
CANCER TREATMENT REVIEWS | 2014年 / 40卷 / 08期
关键词：
Brain metastases; Melanoma; Lung cancer; Breast cancer; Renal cell carcinoma; PHASE-II TRIAL; TYROSINE KINASE INHIBITORS; DISSEMINATED MALIGNANT-MELANOMA; LAPATINIB PLUS CAPECITABINE; CYTOKINE WORKING GROUP; OPEN-LABEL; RADIATION-THERAPY; SOLID TUMORS; CEREBRAL METASTASES; TARGETED THERAPY;
D O I：
10.1016/j.ctrv.2014.05.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The frequency of metastatic brain tumors has increased over recent years; the primary tumors most involved are breast cancer, lung cancer, melanoma and renal cell carcinoma. While radiation therapy and surgery remain the mainstay treatment in selected patients, new molecular drugs have been developed for brain metastases. Studies so far report interesting results. This review focuses on systemic cytotoxic drugs and, in particular, on new targeted therapies and their clinically relevant activities in brain metastases from solid tumors in adults. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：951 / 959
页数：9
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