Evaluation of a Commercial Immuno-Chromatographic Assay Kit for Rapid Detection of IgM Antibodies against Leptospira Antigen in Human Serum

被引：7

作者：

Amran, Fairuz ^{[1
]}

Liow, Yii Ling ^{[1
]}

Halim, Nurul Atiqah Noor ^{[1
]}

机构：

[1] Inst Med Res, Infect Dis Res Ctr, Bacteriol Unit, Jalan Pahang, Kuala Lumpur 50588, Malaysia

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2018年 / 33卷 / 17期

关键词：

Diagnostics; Leptospirosis; Immunochromatographic Test; Serological Tests; Serum IgM Antibodies; DIAGNOSIS;

D O I：

10.3346/jkms.2018.33.e131

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leptospirosis is a febrile zoonotic disease. Routine diagnosis of leptospirosis is based on the detection of specific antibodies with serological tests. The aim of our study was to determine the usefulness of immunochromatographic assay (ICA), ImmuneMed Leptospira IgM Duo Rapid test kit from Korea, in rapid screening of acute leptospirosis in emergency cases with limited expertise. A total of 197 serum samples (93 positive, 104 negative) were selected randomly. The test has good diagnostic sensitivity 73% and specificity 90%. With positive predictive value of 87% and negative predictive value of 79%, this reassures patients have higher chance of correct diagnosis. This ICA is acceptable for screening of leptospirosis but confirmation with microscopic agglutination test should follow.

引用

页数：6

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