Cytokines in neuroinflammation and Alzheimer's disease

被引：191
|
作者：
Cacquevel, M [1 ]
Lebeurrier, N [1 ]
Chéenne, S [1 ]
Vivien, D [1 ]
机构：
[1] Univ Caen, UMR 6185, CNRS, Ctr Cyceron, F-14074 Caen, France
来源：
CURRENT DRUG TARGETS | 2004年 / 5卷 / 06期
关键词：
Alzheimer's disease; inflammation; cytokine; TGF-beta;
D O I：
10.2174/1389450043345308
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Inflammation has been reported in numerous neurodegenerative disorders such as Parkinson's disease. stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located to the vicinity of amlyloid plaques. Cytokines, such as Interleukin-1 (IL-1), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-alpha) and Transforming Growth Factor beta (TGF-beta) have been clearly involved in this inflammatory process. Although their expression is induced by the presence of amyloid-beta peptide, these cytokines are also able to promote the accumulation of amyloid-beta peptide. Altogether, IL-1, IL-6, TNF-alpha and TGT-beta should be considered as key players of a vicious circle leading to the progression of the disease.
引用
收藏
页码：529 / 534
页数：6
相关论文
共 50 条
  • [1] Neuroinflammation in Alzheimer's disease: Pleiotropic roles for cytokines and neuronal pentraxins
    Swanson, Ashley
    Wolf, Tovah
    Sitzmann, Alli
    Willette, Auriel A.
    BEHAVIOURAL BRAIN RESEARCH, 2018, 347 : 49 - 56
  • [2] Neuroinflammation and Alzheimer's disease
    Eikelenboom, P
    NEUROCHEMISTRY: CELLULAR, MOLECULAR, AND CLINICAL ASPECTS, 1997, : 15 - 19
  • [3] Neuroinflammation in Alzheimer's Disease
    Onyango, Isaac G.
    Jauregui, Gretsen V.
    Carna, Maria
    Bennett, James P.
    Stokin, Gorazd B.
    BIOMEDICINES, 2021, 9 (05)
  • [4] Neuroinflammation in Alzheimer's disease
    Heneka, Michael T.
    Carson, Monica J.
    El Khoury, Joseph
    Landreth, Gary E.
    Brosseron, Frederic
    Feinstein, Douglas L.
    Jacobs, Andreas H.
    Wyss-Coray, Tony
    Vitorica, Javier
    Ransohoff, Richard M.
    Herrup, Karl
    Frautschy, Sally A.
    Finsen, Bente
    Brown, Guy C.
    Verkhratsky, Alexei
    Yamanaka, Koji
    Koistinaho, Jari
    Latz, Eicke
    Halle, Annett
    Petzold, Gabor C.
    Town, Terrence
    Morgan, Dave
    Shinohara, Mari L.
    Perry, V. Hugh
    Holmes, Clive
    Bazan, Nicolas G.
    Brooks, David J.
    Hunot, Stephane
    Joseph, Bertrand
    Deigendesch, Nikolaus
    Garaschuk, Olga
    Boddeke, Erik
    Dinarello, Charles A.
    Breitner, John C.
    Cole, Greg M.
    Golenbock, Douglas T.
    Kummer, Markus P.
    LANCET NEUROLOGY, 2015, 14 (04): : 388 - 405
  • [5] Neuroinflammation in Alzheimer's disease
    Gate, David
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2021, 429
  • [6] Neuroinflammation in Alzheimer's disease
    Zhang, Fengjin
    Jiang, Linlan
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2015, 11 : 243 - 256
  • [7] Neuroinflammation in Alzheimer's disease and prion disease
    Eikelenboom, P
    Bate, C
    Van Gool, WA
    Hoozemans, JJM
    Rozemuller, JM
    Veerhuis, R
    Williams, A
    GLIA, 2002, 40 (02) : 232 - 239
  • [8] Neuroinflammation in Alzheimer's disease continuum
    Taskiran-Sag, Aslihan
    Yemisci, Muge
    NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, 2020, 37 (04): : 155 - 163
  • [9] Neuroinflammation and Neuroimmunomodulation in Alzheimer’s Disease
    Hong Y.
    Xu J.
    Hu Y.
    Li L.
    Dong Z.
    Zhu T.-K.
    Wei Y.-Q.
    Current Pharmacology Reports, 2018, 4 (5) : 408 - 413
  • [10] Neuroinflammation as motor of Alzheimer's disease
    Castro-Gomez, Sergio
    Binder, Julius
    Heneka, Michael T.
    NERVENARZT, 2019, 90 (09): : 898 - 906
12345