Osthole suppresses seizures in the mouse maximal electroshock seizure model

被引：70
|
作者：
Luszczki, Jarogniew J. [1 ,2 ]
Andres-Mach, Marta [2 ]
Cisowski, Wojciech [3 ]
Mazol, Irena [3 ]
Glowniak, Kazimierz [4 ]
Czuczwar, Stanislaw J. [1 ,2 ]
机构：
[1] Med Univ Lublin, Dept Pathophysiol, PL-20090 Lublin, Poland
[2] Inst Agr Med, Dept Physiopathol, PL-20950 Lublin, Poland
[3] Wroclaw Med Univ, Dept Pharmacognosy, PL-50140 Wroclaw, Poland
[4] Med Univ Lublin, Med Plants Lab, Dept Pharmacognosy, PL-20093 Lublin, Poland
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2009年 / 607卷 / 1-3期
关键词：
Osthole; Maximal electroshock seizure test; RABBIT CORPUS CAVERNOSUM; ANGELICA-PUBESCENS; CNIDIUM-MONNIERI; IN-VITRO; IMPERATORIN; COUMARINS; FRUITS; DRUGS; MICE; VIVO;
D O I：
10.1016/j.ejphar.2009.02.022
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to determine the anticonvulsant effects of osthole ([7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one] - a natural coumarin derivative) in the mouse maximal electroshock-induced seizure model. The antiseizure effects of osthole were determined at 15, 30, 60, and 120 min after its systemic (i.p.) administration. Time course of anticonvulsant action of osthole revealed that the natural coumarin derivative produced a clear-cut antielectroshock activity in mice and the experimentally-derived ED(50) values for osthole ranged from 259 to 631 mg/kg. In conclusion, osthole suppresses seizure activity in the mouse maximal electroshock-induced seizure model. It may become a novel treatment option following further investigation in other animal models of epilepsy and preclinical studies. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：107 / 109
页数：3
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