PDGF and TGF-β partially prevent 2-deoxy-D-ribose-induced apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar

被引：14
|
作者：
Ottaviani, E
Barbieri, D
Franchini, A
Kletsas, D
机构：
[1] Univ Modena & Reggio Emilia, Dept Anim Biol, I-41100 Modena, Italy
[2] Univ Modena & Reggio Emilia, Gen Pathol Sect, Dept Biomed Sci, I-41100 Modena, Italy
[3] Natl Ctr Sci Res Demokritos, Inst Biol, GR-15310 Athens, Greece
来源：
JOURNAL OF INSECT PHYSIOLOGY | 2000年 / 46卷 / 01期
关键词：
insect cell line (IPLB-LdFB); PDGF-AB; TGF-beta; 1; 2-deoxy-D-ribose; apoptosis;
D O I：
10.1016/S0022-1910(99)00104-3
中图分类号：
Q96 [昆虫学];
学科分类号：
摘要：
The IPLB-LdFB cell line from the fat body of the insect Lymantria dispar shows the presence of immunoreactive, platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-beta 1 molecules, as well as the corresponding plasma membrane-like receptors, i.e. PDGFR-alpha, PDGFR-beta and TGFR-beta type II. Cytofluorimetric and morphological studies reveal that the reducing sugar 2-deoxy-D-ribose (dRib), an apoptotic agent for human cells, induces apoptosis in a concentration- and time-dependent manner even in IPLB-LdFB cells. PDGF-AB and TGF-beta 1 partially counteract the effect of dRib, indicating a survival role of these factors in this apoptotic model of insect cells. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：81 / 87
页数：7
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