Association Between TNF- Promoter-308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case-Control Study and Meta-Analysis

被引:22
|
作者
Yang, Z-C [1 ]
Xu, F. [1 ]
Tang, M. [1 ]
Xiong, X. [2 ]
机构
[1] Southwest Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp, Luzhou, Sichuan, Peoples R China
[2] Southwest Med Univ, Dept Dermatol, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China
关键词
NECROSIS-FACTOR-ALPHA; THAN-G POLYMORPHISMS; GENE POLYMORPHISMS; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASES; POPULATION; SLE; HLA-DR3; REGION; CONTRIBUTE;
D O I
10.1111/sji.12516
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The tumour necrosis factor- (TNF-) promoter -308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF- -308 A/G and SLE risk. However, results were inconsistent. A case-control study was carried out to explore the association between TNF- -308 A/G and the SLE risk in a Chinese Han population. Meta-analysis combining present with previous studies was conducted to further explore the association. Our case-control study included 556 patients with SLE along with 570 matched healthy controls. TNF- -308 A allele was significantly increased in patients with SLE compared with controls (OR=2.184, 95% CI: 1.718-2.778, P<0.001). Genotypes AA and AG were associated with the susceptibility to SLE as compared with the GG genotype, as well as the dominant model (AA+AG versus GG), respectively. The meta-analysis included 41 comparative studies involving 4799 patients and 6635 controls. An association between SLE and allele A was found in the overall populations (OR=1.70, 95% CI: 1.46-1.98, P<0.001). In addition, we discussed the correlation between this polymorphism and lupus nephritis (LN) risk, showing that allele A was significantly related to LN in the overall populations (OR=1.80, 95% CI: 1.21-2.68, P=0.004). The results from our case-control study and the meta-analysis indicate that the TNF- -308 A allele is significantly associated with an increased risk of SLE/LN.
引用
收藏
页码:197 / 210
页数:14
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