Role of D-Dimer, CRP as Prognostic Indicator in COVID-19 Infection: A Review Study

Corona virus disease 2019 has evolved as a pandemic now a day and become medical, social and psychological. COVID-19 belongs to Coronavirade COVID-19 infection initiates with the bats and spread in humans by an unknown medium in China. Infected droplet inhalation and close interaction caused its spread in humans. COVID-19 virus has its incubation period of 2 to 14 days. The disease first reported during an investigation an outbreak in wuhan part of Hubei province China, started from December 8, 2019 by several cases of pneumonia unknown aetiology with sever acute respiratory distress and other serious complications like increased endothelial damage and micro thrombi formation Sometimes the manifestation of COVID-19 infection is unpredictable from asymptomatic to symptomatic that is sore throat, nausea, loss of smell and test, etc. there are various biomarkers are available, which could be used in prediction of the severity of COVID-19 infection. Main aim of the study to provide spectrum about D-dimer and C-Reactive Protein (CRP) as prognostic indicator in COVID-19 infection. The review data were gathered from PubMed, Scopus and science direct by using key word COVID-19, SARSE-2, and biomarkers, studies with clear outcome were selected. Raised serum level of D-dimer was first observed in the Wuhan Hubei province China by a physician in January 2020 and then Maximum research findings indicated that increase in CRP and D-dimer level among the patients with severe COVID-19 infections. Although further research is required to observe changes in many biomarkers during course of disease.