Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes

被引：10

作者：

Bi, Xiu-Zeng ^{[1
]}

Pan, Wei-Hua ^{[1
]}

Yu, Xin-Ping ^{[1
]}

Song, Zong-Ming ^{[1
]}

Ren, Zeng-Jin ^{[2
]}

Sun, Min ^{[2
]}

Li, Cong-Hui ^{[2
]}

Nan, Kai-Hui ^{[3
]}

机构：

[1] Wenzhou Med Coll, Hosp Optometry & Ophthalmol, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Coll, Sch Optometry & Ophthalmol, Wenzhou 325027, Zhejiang, Peoples R China

[3] Wenzhou Engn Res Ctr Biomat, Wenzhou 325027, Zhejiang, Peoples R China

来源：

PLOS ONE | 2015年 / 10卷 / 11期

关键词：

OPTICAL COHERENCE TOMOGRAPHY; MITOMYCIN-C; FILTRATION SURGERY; ANTERIOR SEGMENT; 5-FLUOROURACIL; POLYPROPYLENE; MICROSPHERES;

D O I：

10.1371/journal.pone.0141467

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes. Eighteen New Zealand white rabbits were randomly divided into three groups (A, B and C; n = 6 per group). Group A received combined 5-Fu-polycaprolactone sustained-release film application and Ahmed glaucoma valve implantation, group B received local infiltration of 5-Fu and Ahmed glaucoma valve implantation, and group C received Ahmed glaucoma valve implantation. Postoperative observations were made of the anterior segment, intraocular pressure, central anterior chamber depth, blebs, drainage tube, and accompanying ciliary body detachment. The pathology of the blebs and surrounding tissues were observed at month 3 postoperatively. We revealed that the 5-Fu-polycaprolactone sustained-release film maintained a release concentration range of 13.7 +/- 0.12 to 37.41 +/- 0.47 mu g/ml over three months in vitro. Postoperatively, diffuse blebs with ridges were found in all eyes in group A, two blebs were observed in group B, and no bleb formation was present in group C. The postoperative central anterior chamber depth in group A was significantly less than that of the other two groups. The postoperative intraocular pressure of group A stabilized at 6.33-8.67 mmHg, whereas that of group C gradually remained at 7.55-10.02 mmHg. The histopathology showed that the fibrous tissue thickness of the blebs in group A was significantly thinner than that of the other groups. We conclude that the 5-Fu-polycaprolactone sustained-release film had a sustained drug release effect, which promoted the inhibition of bleb scarring after Ahmed glaucoma valve implantation.

引用

页数：12