Inhibitory Effect of Trans-10, Cis-12 Conjugated Linoleic Acid on Growth of Neural Stem Cells

被引：0
|
作者：
Wang, Han [1 ]
Wang, Jihui [1 ]
Ye, Shuhong [1 ]
机构：
[1] Dalian Polytech Univ, Sch Food Sci & Technol, Liaoning Key Lab Food Biol Technol, Dalian, Peoples R China
来源：
ISBE 2011: 2011 INTERNATIONAL CONFERENCE ON BIOMEDICINE AND ENGINEERING, VOL 4 | 2011年
关键词：
Trans-10; Cis-12 Conjugated Linoleic Acid; Cell growth; Neural stem cells; PROGENITOR CELLS; PROTEIN;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The objective of this study was to examine the influence of trans-10, cis-12 conjugated linoleic acid on the proliferation capacity of neural stem cells in vitro. Morphological observation showed that more neural stem cells failed to form neurospheres compared with that observed with control neural stem cells. Cell counts showed that treatment of neural stem cells with trans-10, cis-12 conjugated linoleic acid decreased the cell number in a dose- and time- dependent manner. Western blot analysis revealed the reduced expression of cyclin D1 induced by trans-10, cis-12 treatment. These results suggested that trans-10, cis-12 conjugated linoleic acid inhibited the proliferation of neural stem cells. The effect of trans-10, cis-12 conjugated linoleic acid may be associated with the down-regulation of cyclin D1 expression.
引用
收藏
页码：242 / 245
页数：4
相关论文
共 10 条
  • [1] REGULATION OF THE RETINOBLASTOMA PROTEIN-RELATED P107 BY G(1) CYCLIN COMPLEXES
    BEIJERSBERGEN, RL
    CARLEE, L
    KERKHOVEN, RM
    BERNARDS, R
    [J]. GENES & DEVELOPMENT, 1995, 9 (11) : 1340 - 1353
  • [2] Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells
    Guan, Shui
    Ge, Dan
    Liu, Tian-Qing
    Ma, Xue-Hu
    Cui, Zhan-Feng
    [J]. TOXICOLOGY IN VITRO, 2009, 23 (02) : 201 - 208
  • [3] DOCOSAHEXAENOIC ACID PROMOTES NEURONAL DIFFERENTIATION BY REGULATING BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS AND CELL CYCLE IN NEURAL STEM CELLS
    Katakura, M.
    Hashimoto, M.
    Shahdat, H. M.
    Gamoh, S.
    Okui, T.
    Matsuzaki, K.
    Shido, O.
    [J]. NEUROSCIENCE, 2009, 160 (03) : 651 - 660
  • [4] Docosahexaenoic acid promotes neurogenesis in vitro and in vivo
    Kawakita, E.
    Hashimoto, M.
    Shido, O.
    [J]. NEUROSCIENCE, 2006, 139 (03) : 991 - 997
  • [5] CNS STEM-CELLS EXPRESS A NEW CLASS OF INTERMEDIATE FILAMENT PROTEIN
    LENDAHL, U
    ZIMMERMAN, LB
    MCKAY, RDG
    [J]. CELL, 1990, 60 (04) : 585 - 595
  • [6] Lie DC, 2002, J NEUROSCI, V22, P6639
  • [7] Lillien L, 2000, DEVELOPMENT, V127, P4993
  • [8] Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization
    Muntean, Andrew G.
    Pang, Liyan
    Poncz, Mortimer
    Dowdy, Steven F.
    Blobel, Gerd A.
    Crispino, John D.
    [J]. BLOOD, 2007, 109 (12) : 5199 - 5207
  • [9] GENERATION OF NEURONS AND ASTROCYTES FROM ISOLATED CELLS OF THE ADULT MAMMALIAN CENTRAL-NERVOUS-SYSTEM
    REYNOLDS, BA
    WEISS, S
    [J]. SCIENCE, 1992, 255 (5052) : 1707 - 1710
  • [10] Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression
    Tashiro, Etsu
    Tsuchiya, Ayako
    Imoto, Masaya
    [J]. CANCER SCIENCE, 2007, 98 (05): : 629 - 635
1