Behavioral effects of developmental methylmercury drinking water exposure in rodents

被引：38
|
作者：
Bisen-Hersh, Emily B. [1 ]
Farina, Marcelo [4 ]
Barbosa, Fernando, Jr. [5 ]
Rocha, Joao B. T. [6 ]
Aschner, Michael [1 ,2 ,3 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Med Ctr, Kennedy Ctr Res Human Dev, Dept Pharmacol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Med Ctr, Ctr Mol Toxicol, Nashville, TN 37232 USA
[4] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Bioquim, Florianopolis, SC, Brazil
[5] Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Sao Paulo, Brazil
[6] Univ Fed Santa Maria, Dept Quim, BR-97119900 Santa Maria, RS, Brazil
来源：
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2014年 / 28卷 / 02期
关键词：
Mercury; Developmental neurotoxicity; Behavior; Rodents; Learning; DEPRESSION-LIKE BEHAVIOR; PROTEIN-KINASE-C; GESTATIONAL EXPOSURE; PRENATAL EXPOSURE; METHYL MERCURY; OXIDATIVE STRESS; DISCRIMINATION REVERSAL; PERINATAL EXPOSURE; LIFETIME EXPOSURE; OPERANT-BEHAVIOR;
D O I：
10.1016/j.jtemb.2013.09.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising froth this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed. (c) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码：117 / 124
页数：8
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