Resolution of fetal goiter after discontinuation of propylthiouracil in a pregnant woman with Graves' hyperthyroidism

被引:26
|
作者
Ochoa-Maya, MR
Frates, MC
Lee-Parritz, A
Seely, EW
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Endocrine Hypertens Div, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Obstet & Gynecol, Boston, MA 02115 USA
关键词
D O I
10.1089/thy.1999.9.1111
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a case of Graves' hyperthyroidism in a 34-year-old pregnant woman treated with propylthiouracil (PTU) complicated by the development of a fetal goiter. Because of the fetal goiter and normal maternal thyroid function tests, the PTU was discontinued. Over the next 10 weeks, there was a progressive decrease in the fetal thyroid volume as documented by ultrasonography. The fetal neck returned to a normal flexed position, fetal growth and amniotic fluid remained normal, and the patient remained asymptomatic. A normal infant was delivered at term. This is the first report to demonstrate that noninvasive management may be appropriate for fetuses with goiter caused by antithyroid drug therapy.
引用
收藏
页码:1111 / 1114
页数:4
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