The role of high-mobility group protein box 1 in lung cancer

被引：20
|
作者：
Wu, Xiao-Jin [1 ,2 ]
Chen, Yuan-Yuan [1 ]
Gong, Chan-Chan [2 ]
Pei, Dong-Sheng [2 ]
机构：
[1] First Peoples Hosp Xuzhou, Dept Radiat Oncol, Xuzhou, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Dept Pathol, 209 Tong Shan Rd, Xuzhou 221004, Jiangsu, Peoples R China
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2018年 / 119卷 / 08期
基金：
中国国家自然科学基金;
关键词：
high-mobility group protein box 1 (HMGB1); lung cancer; metastasis; RAGE; TLRs; GLYCATION END-PRODUCTS; HMGB1; PROMOTES; CELL-MIGRATION; CLINICAL-VALUE; TUMOR-GROWTH; DNA-BINDING; RECEPTOR; KAPPA-B; ACTIVATION; EXPRESSION;
D O I：
10.1002/jcb.26837
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
High-mobility group protein box 1(HMGB1)is a ubiquitous highly conserved nuclear protein. Acting as a chromatin-binding factor, HMGB1 binds to DNA and plays an important role in stabilizing nucleosome formation, facilitating gene transcription, DNA repairing, inflammation, cell differentiation, and regulating the activity of steroid hormone receptors. Currently, HMGB1 is discovered to be related to development, progression, and targeted therapy of lung cancer, which makes it an attractive biomarker, and therapeutic target. This review aims to encapsulate the relationship between HMGB1 and lung cancer, suggesting that HMGB1 plays a pivotal role in initiation, development, invasion, metastasis, and prognosis of lung cancer.
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页码：6354 / 6365
页数：12
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