Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection

被引：16

作者：

Asquith, Christopher R. M. ^{[1
]}

Meli, Marina L. ^{[2
,3
]}

Konstantinova, Lidia S. ^{[4
]}

Laitinen, Tuomo ^{[5
]}

Perakyla, Mikael ^{[5
]}

Poso, Antti ^{[5
]}

Rakitin, Oleg A. ^{[4
]}

Allenspach, Karin ^{[6
]}

Hofmann-Lehmann, Regina ^{[2
,3
]}

Hilton, Stephen T. ^{[1
]}

机构：

[1] UCL, Fac Life Sci, Sch Pharm, London WC1N 1AX, England

[2] Univ Zurich, Vetsuisse Fac, Clin Lab, CH-8057 Zurich, Switzerland

[3] Univ Zurich, Vetsuisse Fac, Ctr Clin Studies, CH-8057 Zurich, Switzerland

[4] Russian Acad Sci, Zelinsky Inst Organ Chem, Moscow 119991, Russia

[5] Univ Eastern Finland, Fac Hlth Sci, Sch Pharm, Kuopio 70211, Finland

[6] Royal Vet Coll, Hatfield AL9 7TA, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 12期

关键词：

FIV; HIV-1; Scorpionine; Nucleocapsid protein; NCp7; NUCLEOCAPSID PROTEIN; SULFUR MONOCHLORIDE; ZINC EJECTION; ANTI-HIV; INHIBITORS; IDENTIFICATION; MUTATIONS; DOMAINS; TARGET; ASSAY;

D O I：

10.1016/j.bmcl.2014.04.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

引用

页码：2640 / 2644

页数：5

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