Impact of Adverse Events Following Immunization in Viet Nam in 2013 on chronic hepatitis B infection

被引:24
|
作者
Li, Xi [1 ]
Wiesen, Eric [2 ]
Diorditsa, Sergey [2 ]
Toda, Kohei [3 ]
Thi Hong Duong [4 ]
Lien Huong Nguyen [4 ]
Van Cuong Nguyen [4 ]
Tran Hien Nguyen [4 ]
机构
[1] Johns Hopkins Univ, Master Sci Publ Hlth, 615 N Wolfe St, Baltimore, MD 21205 USA
[2] World Hlth Org, Western Pacific Reg Off, Expanded Programme Immunizat Unit, POB 2932, Manila, Philippines
[3] World Hlth Org, Country Off, Expanded Programme Immunizat Unit, 63 Tran Hung Dao St, Hanoi, Vietnam
[4] Natl Inst Hyg & Epidemiol, 1 Yersin St, Hanoi 10000, Vietnam
关键词
Adverse events following immunization; Hepatitis B; Vaccination coverage; Viet Nam; Disease burden; REPRODUCTIVE-TRACT INFECTIONS; RURAL VIETNAM; VACCINATION; PREVALENCE; EFFICACY; WOMEN;
D O I
10.1016/j.vaccine.2015.05.067
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Adverse Events Following Immunization in Viet Nam in 2013 led to substantial reductions in hepatitis B vaccination coverage (both the birth dose and the three-dose series). In order to estimate the impact of the reduction in vaccination coverage on hepatitis B transmission and future mortality, a widely-used mathematical model was applied to the data from Viet Nam. Using the model, we estimated the number of chronic infections and deaths that are expected to occur in the birth cohort in 2013 and the number of excessive infections and deaths attributable to the drop in immunization coverage in 2013. An excess of 90,137 chronic infections and 17,456 future deaths were estimated to occur in the 2013 birth cohort due to the drop in vaccination coverage. This analysis highlights the importance of maintaining high vaccination coverage and swiftly responding to reported Adverse Events Following Immunization in order to regain consumer confidence in the hepatitis B vaccine. (C) 2015 World Health Organization; licensee Elsevier. Published by Elsevier Ltd.
引用
收藏
页码:869 / 873
页数:5
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