Patterns of Infancy Growth and Metabolic Hormonal Profile Are Different in Very-Low-Birth-Weight Preterm Infants Born Small for Gestational Age Compared to Those Born Appropriate for Gestational Age

被引:7
|
作者
Isabel Hernandez, Maria [1 ]
Rossel, Katherine [2 ]
Pena, Veronica [1 ,2 ]
Garcia, Mirna [2 ]
Cavada, Gabriel [3 ,4 ]
Avila, Alejandra [1 ]
Iniguez, German [1 ]
Mericq, Veronica [1 ]
机构
[1] Univ Chile, Fac Med, Inst Maternal & Child Res, POB 226-3, Santiago, Chile
[2] Hosp San Borja Arriaran, Unit Neonatol, Dept Pediat, Santiago, Chile
[3] Univ Chile, Dept Publ Hlth, Santiago, Chile
[4] Univ Los Andes, Santiago, Chile
来源
HORMONE RESEARCH IN PAEDIATRICS | 2018年 / 89卷 / 04期
关键词
Preterm infants; Small for gestational age; Very low birth weight; Early growth; Metabolic changes; CATCH-UP GROWTH; INSULIN SENSITIVITY; FACTOR-I; BODY-COMPOSITION; PREMATURE-INFANTS; POSTNATAL-GROWTH; FETAL-GROWTH; IGF-I; CHILDREN; SECRETION;
D O I
10.1159/000487994
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: An increased preterm birth survival rate is associated with long-term neurological and metabolic risks; thus, our aim was to evaluate whether early patterns of infancy anthropometry and metabolic hormonal profile differ in preterm infants born small for gestational age (SGA) or appropriate for gestational age (AGA) from birth to 36 months of corrected age (CA). Methods: We recruited 110 very-low-birth-weight (VLBW) preterm infants (AGA = 60 and SGA = 50) with a mean birth weight of -2.39 +/- 0.77 versus 0.57 +/- 0.54 standard deviation scores (SDS) (p < 0.01) and birth length of -2.1 +/- 1.05 versus -0.44 +/- 0.82 SDS (p < 0.01), respectively. Anthropometry and blood sampling for insulin, insulin-like growth factor (IGF)-II, IGF-I, and leptin were performed for up to 3 years. Results: All neonates increased their weight, length, and head circumference SDS during the early inpatient period. Up to 90% reached a normal length within this period. The IGF-II, insulin, and glycemia concentrations changed in parallel with weight. In the first year of CA, only SGA infants gained weight and height SDS. The homoeostatic model assessment had a trend toward higher values in SGA infants at 24 and 36 months (p = 0.06 and p = 0.07). Conclusion: Being SGA is the strongest predictor of early recovery of height in VLBW preterm infants. Follow-up will allow us to determine whether the differences in the growth patterns of VLBW preterm infants by birth weight SDS persist. (C) 2018 S. Karger AG, Basel.
引用
收藏
页码:233 / 245
页数:13
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