Targeting copper metabolism to defeat KRAS-driven colorectal cancer

被引：7
|
作者：
Aubert, Leo [1 ]
Nandagopal, Neethi [1 ]
Roux, Philippe P. [1 ,2 ]
机构：
[1] Univ Montreal, Inst Res Immunol & Canc IRIC, Montreal, PQ, Canada
[2] Univ Montreal, Dept Pathol & Cell Biol, Fac Med, Montreal, PQ, Canada
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2020年 / 7卷 / 06期
关键词：
Copper; KRAS; TTM; ATP7A; colorectal cancer; chelators; micronutrients;
D O I：
10.1080/23723556.2020.1822123
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, which reveals copper metabolism as a promising therapeutic target for KRAS-driven colorectal cancers.
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页数：2
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