Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36

被引：55
|
作者：
Chomcheon, Porntep [1 ,2 ]
Wiyakrutta, Suthep [3 ,4 ]
Sriubolmas, Nongluksna [5 ]
Ngamrojanavanich, Nattaya [2 ,6 ,7 ]
Kengtong, Surapong [8 ]
Mahidol, Chulabhorn [1 ,9 ,10 ,11 ]
Ruchirawat, Somsak [1 ,9 ,10 ,11 ]
Kittakoop, Prasat [1 ,9 ,10 ]
机构：
[1] Chulabhorn Res Inst, Bangkok 10210, Thailand
[2] Chulalongkorn Univ, Program Biotechnol, Fac Sci, Bangkok 10330, Thailand
[3] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand
[4] Ctr Bioact Nat Prod Marine Organisms & Endophyt F, Bangkok 10400, Thailand
[5] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok 10330, Thailand
[6] Ctr Bioact Nat Prod Marine Organisms & Endophyt F, Bangkok 10330, Thailand
[7] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand
[8] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmaceut Bot, Bangkok 10330, Thailand
[9] Chulabhorn Grad Inst, Bangkok 10210, Thailand
[10] Ctr Environm Hlth Toxicol & Management Chem ETM, Bangkok 10210, Thailand
[11] Mahidol Univ, Chulabhorn Res Ctr, Inst Sci & Technol Res & Dev, Bangkok 10700, Thailand
来源：
PHYTOCHEMISTRY | 2009年 / 70卷 / 03期
关键词：
Corynespora cassiicola; Endophytic fungi; Depsidone; Diaryl ether; Aromatase inhibitor; Radical scavenging; Antioxidant activity; Cytotoxic activity; COLORIMETRIC ASSAY; NATURAL-PRODUCTS; LICHEN; METABOLITES; CANCER; DERIVATIVES;
D O I：
10.1016/j.phytochem.2009.01.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50 value of 5.30 mu M. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：407 / 413
页数：7
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