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Structural and functional properties of Yersinia pestis Caf1 capsular antigen and their possible role in fulminant development of primary pneumonic plague

被引：10
|
作者：
Abramov, YM
Vasiliev, AM
Khlebnikov, VA
Vasilenko, RN
Kulikova, NL
Kosarev, IV
Ishchenko, AT
Gillespie, JR
Millett, IS
Fink, AL
Uversky, VN [1 ]
机构：
[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[2] Russian Acad Sci, Inst Biol Instrumentat, Pushchino 142292, Moscow Region, Russia
[3] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[4] Stanford Univ, Dept Phys, Stanford, CA 94305 USA
[5] Inst Immunol Engn, Lyubuchany 142380, Moscow Region, Russia
来源：
JOURNAL OF PROTEOME RESEARCH | 2002年 / 1卷 / 04期
关键词：
bubonic plague; pneumonic plague; capsular antigen Caf1; molecular adhesin; conformational stability;
D O I：
10.1021/pr025511u
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Yersinia pestis capsular antigen Caf1 is shown to be a beta-structural protein that in polymeric form possesses very high conformational stability. Different approaches show that a dimer is the minimal cooperative block of Caf1 adhesin. Caf1 dimer interacts effectively with IL-1 receptors of human macrophage and epithelial cells. The specificity of such interaction is confirmed by the inhibition of IL-1alpha binding by Caf1. The Caf1 role in pneumonic plague pathogenesis is discussed.
引用
收藏
页码：307 / 315
页数：9
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