Biochemical mechanisms of drug action: what does it take for success?

被引：298

作者：

Swinney, DC ^{[1
]}

机构：

[1] Roche Palo Alto, Palo Alto, CA 94304 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 09期

关键词：

D O I：

10.1038/nrd1500

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Drug discovery is extremely difficult. There are many unanticipated scientific, medical and business challenges to every drug discovery programme. It is important to increase our understanding of the fundamental properties of effective drugs so that we can anticipate potential problems in developing new agents. This article addresses potential drug discovery and development risks associated with the biochemical mechanism of drug action, and proposes simple rules to minimize these risks.

引用

页码：801 / 808

页数：8

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