Time-resolved fluorescence spectroscopy of human brain tumors

被引：6
|
作者：
Marcu, L [1 ]
Thompson, RC [1 ]
Garde, S [1 ]
Sedrak, M [1 ]
Black, KL [1 ]
Yong, WH [1 ]
机构：
[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
来源：
OPTICAL BIOPSY IV | 2002年 / 4613卷
关键词：
time-resolved laser induced fluorescence; brain tumor; glioma; spectroscopy;
D O I：
10.1117/12.465244
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Fluorescence spectroscopy of the endogenous emission of brain tumors has been researched as a potentially important method for the intraoperative localization of brain tumor margins. In this study, we investigate the use of time-resolved laser-induced. fluorescence spectroscopy (TR-LIFS) for demarcation of primary brain tumors by studying the time-resolved spectra of gliomas of different histologic grades. Time-resolved fluorescence (3 ns, 337 nm excitation) from excised human brain tumor show differences between the time-resolved emission of malignant glioma and normal brain tissue (gray and white matter). Our findings suggest that brain tumors can be differentiated from normal brain tissue based upon unique time-resolved fluorescence signature.
引用
收藏
页码：183 / 187
页数：5
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