Modulation of the Renin-Angiotensin-Aldosterone System in Heart Failure

被引：26
|
作者：
George, J. [1 ]
Struthers, A. D. [1 ]
Lang, C. C. [1 ,2 ]
机构：
[1] Univ Dundee, Med Res Inst, Div Cardiovasc & Diabet Med, Dundee, Scotland
[2] Ninewells Hosp & Med Sch, Div Cardiovasc & Diabet Med, Dundee DD1 9SY, Scotland
来源：
CURRENT ATHEROSCLEROSIS REPORTS | 2014年 / 16卷 / 04期
关键词：
Novel therapy; Treatment; Drugs; Renin-angiotensin-aldosterone blockers; Chronic heart failure; Reduced/preserved ejection fraction; PRESERVED EJECTION FRACTION; LEFT-VENTRICULAR DYSFUNCTION; CONVERTING-ENZYME-INHIBITOR; NEUTRAL ENDOPEPTIDASE INHIBITOR; RANDOMIZED ALDACTONE EVALUATION; ACUTE MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; SYSTOLIC FUNCTION; CONTROLLED-TRIAL; DOUBLE-BLIND;
D O I：
10.1007/s11883-014-0403-7
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The renin-angiotensin-aldosterone system (RAAS) is well-established and continues to be pursued as a therapeutic target in the treatment of heart failure, predominantly due to the success of agents that block RAAS in clinical trials of systolic heart failure. The optimal treatment of heart failure patients with preserved ejection fraction (HFpEF), however, remains unclear. Early trials of direct renin inhibitors have suggested that these agents may play a role in HFpEF, but recent clinical trial results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look promising. Whether results with these or other drugs will alter current recommendations remains to be seen. In this review, we assess the current understanding of the role of RAAS modulation in heart failure.
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页数：9
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