Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini-Review

被引：78

作者：

Bettcher, B. M. ^{[1
]}

Kramer, J. H. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2014年 / 96卷 / 04期

关键词：

C-REACTIVE PROTEIN; OLDEST-OLD; METABOLIC SYNDROME; SYSTEMIC INFLAMMATION; DEMENTIA; RISK; SERUM; INTERLEUKIN-6; PROGRESSION; POPULATION;

D O I：

10.1038/clpt.2014.147

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline.

引用

页码：464 / 469

页数：6

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