MIXED-LIGAND COORDINATION POLYMERS: STRUCTURAL DIVERSITY AND PROTECTIVE EFFECT ON CARDIAC ARREST INDUCED BY ANESTHESIA VIA INDUCINGSirt1PATHWAY

被引：1
|
作者：
Xiao, Q. -S. [1 ]
Ren, G. -Z. [2 ]
Li, J. -J. [3 ]
Yin, H. [4 ]
Yu, H. [5 ]
Liu, G. [6 ]
机构：
[1] Guangrao Peoples Hosp Guangrao, Dept Anesthesiol, Guangrao, Shandong, Peoples R China
[2] Yantai Hosp Tradit Chinese Med, Dept Anesthesiol, Yantai, Shandong, Peoples R China
[3] Gaomi Peoples Hosp Shandong Prov, Dept Anesthesiol, Gaomi, Shandong, Peoples R China
[4] Qingdao Univ, Dept Infect Dis, Qingdao Cent Hosp, Qingdao, Shandong, Peoples R China
[5] Shandong First Med Univ, Key Lab Ophthalmol Shandong Prov, Natl Key Lab Cultivat Base Jointly Established Mi, Dept Anesthesiol,Shandong Eye Inst,Qingdao Eye Ho, Qingdao, Shandong, Peoples R China
[6] Bengbu Med Coll, Dept Anesthesiol, Bengbu, Anhui, Peoples R China
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2020年 / 61卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Co(II)-framework; coordination geometry; cardiac arrest; myocardial; MULTICARBOXYLATE; 1,3-DI(1H-IMIDAZOL-4-YL)BENZENE; CADMIUM(II); COMPLEXES; SORPTION;
D O I：
10.1134/S0022476620090127
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A reaction of the N-donor ligand 1,3-di(1H-imidazol-1-yl)benzene (dimb) with Co(NO3)(2 center dot)6H(2)O and the V-shaped carboxylate ligand biphenyl-3,4 ',5-tricarboxylic acid (H(3)bpt) under hydro- or solvothermal conditions yields two new Co(II)-based coordination polymers with the chemical formulas {Co-3(dimb)(2)(bpt)(2)(H2O)(4)]}(n)(1) and [Co-2(dimb)(2)(Hbpt)(2)]center dot H2O (2). Furthermore, the treatment effect of compounds1and2against cardiac arrest induced by anesthesia is evaluated. Firstly, ELISA is used to detect the content of cardiac troponin T and B brain natriuretic peptide after treatment with the compounds. Moreover, RT-PCR is conducted and the relative expression level ofSirt1in the rat myocardial tissue is measured.
引用
收藏
页码：1446 / 1453
页数：8
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