Cobalt-catalyzed asymmetric reactions of heterobicyclic alkenes with in situ generated organozinc halides

被引：19
|
作者：
Li, Yun [1 ]
Chen, Jingchao [1 ]
He, Zhenxiu [1 ]
Qin, Hongyu [1 ]
Zhou, Yongyun [1 ]
Khan, Ruhima [1 ]
Fan, Baomin [1 ,2 ]
机构：
[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 07期
基金：
中国国家自然科学基金;
关键词：
RING-OPENING REACTIONS; AZABICYCLIC ALKENES; OXABICYCLIC ALKENES; ORGANIC-SYNTHESIS; BICYCLIC ALKENES; TANDEM REACTIONS; BARBIER REACTION; BORONIC ACIDS; REAGENTS; AMINES;
D O I：
10.1039/c7qo01064h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general strategy for the asymmetric allylation and benzylation of heterobicyclic alkenes is described by employing in situ generated organozinc halides. This methodology features the application of a co-catalytic system comprising chiral cobalt complex and Lewis acid, which deliver both the asymmetric ring opening products of oxabenzonorbornadienes and the asymmetric addition products of azabenzonorbornadienes, respectively.
引用
收藏
页码：1108 / 1112
页数：5
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