Rubescins A, B and C: New Havanensin Type Limonoids from Root Bark of Trichina rubescens (Meliaceae)

被引：0
|
作者：
Tontsa, Armelle Tsamo [1 ]
Mkounga, Pierre [1 ]
Njayou, Frederic Nico [2 ]
Manautou, Jose [3 ]
Kirk, Marat [4 ]
Hultin, Philip Gregory [4 ]
Nkengfack, Augustin Ephrem [1 ]
机构：
[1] Univ Yaounde I, Dept Organ Chem, Yaounde, Cameroon
[2] Univ Yaounde I, Dept Biochem, Yaounde, Cameroon
[3] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT 06269 USA
[4] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 11期
关键词：
limonoid; Trichilia rubescens; rubescin; antioxidant activity; HUMAN HEPATOMA HEPG2; HYDROGEN-PEROXIDE; CELLS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new limonoids, rubescins A-C (1-3), and three known compounds including, havanensin type limonoid TS3 (4), beta-sitosterol, and stigmasterol were isolated from the root bark of Trichilia rubescens. Their structures were elucidated by means of extensive spectroscopic analyses, particularly one dimensional (1D)- and 2D-NMR techniques in conjunction with mass spectrometry. Rubescins A-C (1-3) and limonoid TS3 (4) were evaluated for their protective effects against oxidative stress induced in HC-04 cells by H2O2. Compound (1) showed strong inhibitory effects on lactase dehydrogenase (LDH) leakage, being as active (IC50 value of 0.0026 mu M) as the positive control quercetin (IC50 value of 0.0030 mu M).
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收藏
页码：1178 / 1183
页数：6
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