Age-Related Changes in Proteoglycan Composition in Rat Brain

被引：1
|
作者：
Leberfarb, E. Yu. [1 ]
Rykova, V. I. [1 ]
Kolosova, N. G. [1 ]
Dymshits, G. M. [1 ]
机构：
[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
proteoglycans; chondroitin sulfates; heparan sulfates; brain; aging;
D O I：
10.1007/s10517-009-0420-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Brain proteoglycans play an important role in learning and memory processes and in the pathogenesis of neurodegenerative disease. Brain proteoglycans in Wistar rats and early aging OXYS rats at the age of 1, 2, and 14 months were compared. Proteoglycan content in OXYS rats aged 1 and 2 months is 2-fold lower than in Wistar. The content of proteoglycans 7-fold decreases in Wistar and OXYS rats with age at the expense of heparan sulfates and chondroitin sulfates and by the age of 14 months, the difference between the strains is leveled. These results indicate that cognitive and emotional disorders observed in OXYS rats by the age of 3 months develop against the background of significant changes in the content and composition of proteoglycans.
引用
收藏
页码：797 / 799
页数：3
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