Analysis of serum corticosteroid-induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases

被引：3
|
作者：
Kojima, K. [1 ]
Ohno, K. [1 ]
Kanemoto, H. [1 ]
Goto-Koshino, Y. [1 ]
Fukushima, K. [1 ]
Tsujimoto, H. [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Tokyo 1138657, Japan
来源：
JOURNAL OF SMALL ANIMAL PRACTICE | 2017年 / 58卷 / 05期
关键词：
GEL DISK-ELECTROPHORESIS; VACUOLAR HEPATOPATHY; SCOTTISH TERRIERS; CIRCADIAN-RHYTHM; DIAGNOSTIC-VALUE; CANINE PLASMA; HYPERADRENOCORTICISM; SEPARATION; CORTISOL; LESIONS;
D O I：
10.1111/jsap.12623
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
OBJECTIVE : To reveal the relationship between canine corticosteroid-induced alkaline phosphatase isoenzyme activity and hepatobiliary diseases. MATERIALS AND METHODS : Retrospective analysis of the relationship between serum corticosteroid-induced alkaline phosphatase activity and diagnosis, serum cortisol concentration and alanine transferase activity in dogs with hepatobiliary diseases. Dogs with a history of glucocorticoid administration were excluded. RESULTS : Seventy-two dogs with hepatobiliary diseases were analysed. The serum corticosteroid-induced alkaline phosphatase concentration was increased in dogs with hepatobiliary diseases. There was no correlation between serum cortisol concentration and serum corticosteroid-induced alkaline phosphatase percentage or activity. CLINICAL SIGNIFICANCE : Dogs with hepatobiliary disease can exhibit high serum alkaline phosphatase activity even if the dogs have not been administrated glucocorticoids and the serum cortisol concentration is normal.
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页码：257 / 262
页数：6
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