Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

被引：39
|
作者：
Malhotra, Sanjay V. [1 ]
Kumar, Vineet [1 ]
Velez, Christian [2 ]
Zayas, Beatriz [2 ]
机构：
[1] Leidos Biomed Res Inc, Lab Synthet Chem, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA
[2] Univ Metropolitana, Sch Environm Affairs, San Juan, PR 00928 USA
来源：
MEDCHEMCOMM | 2014年 / 5卷 / 09期
基金：
美国国家卫生研究院;
关键词：
THALIDOMIDE; FRAGMENTATION; DEATH;
D O I：
10.1039/c4md00161c
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose. Their effects on annexin V, DNA fragmentation, and the cell cycle, together with mitochondrial membrane permeabilization tests, provide insights into their mechanism of action. Also, experiments with A431 human epidermoid carcinoma cells suggest the activation of an apoptotic pathway, due to activity of the initiator caspase 8 and effector caspase 3.
引用
收藏
页码：1404 / 1409
页数：6
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